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May 17, 2021 · Dengue 1 virus: DENV-1: Flavivirus: Yes a (severe) 1634: 10,500: Dengue 2 virus: DENV-2: Flavivirus: Yes a (severe) 1184: 9750: Dengue 3 virus: DENV-3: Flavivirus: Yes a (severe) 772: 10,590: Dengue 4 virus: DENV-4: Flavivirus: Yes a (severe) 176: 9730: Zika virus: ZIKV: Flavivirus: No: 258: 10,120: Chikungunya virus: CHIKV: Togavirus: Yes a ...
- Riccardo Delli Ponti, Marek Mutwil
- 10.1186/s12864-021-07638-7
- 2021
- BMC Genomics. 2021; 22: 352.
- Structural Properties of The Denv Genomes
- Comparison of Structural Properties of The VHF Genomes
- Structural Content Can Be Used to Classify Vhfs
- Geographical Distribution of Denv Serotypes
Here, we analysed the secondary structure profiles of the complete genomes of more than 7000 ss-RNA viruses (Table 1; Methods: Source of viral genomes). The structural profiles were generated using the CROSS algorithm, a fast and comprehensive alternative to profile the structural content (i.e., % of double-stranded nucleotides) of long and complex...
Interestingly, DENV serotypes tend to be less structured than other flaviviruses, such as West Nile Fever virus (WNV), Yellow Fever virus (YFV), Tick-borne Encephalitis virus (TBV), and Japanese Encephalitis virus (JEV; Fig. 2). Even if not properly a VHF, we also used as comparison Zika virus (ZIKV), due to the similarities with DENV not only in t...
The overall similarities and differences in structure are an additional feature that could be employed to characterise the different viruses. For the next step, the structural content (mean of the % of double-stranded nucleotides for all the viral genomes) in a specific species was used to hierarchically group the 11 different viruses (Methods: Hie...
We also studied the geographical connection between DENV serotypes and the secondary structure content. We found that the African DENV-1 is predicted to be more structured than the other serotypes, even when compared with the Asian strains (Supplementary Figure 5 Kolmogorov-Smirnov = 0.001), while on the contrary, Asian DENV-3 is more structured th...
- Riccardo Delli Ponti, Marek Mutwil
- 2021
May 11, 2021 · Using these techniques, the researchers confirmed six protein-coding genes in the SARS-CoV-2 genome in addition to the five that are well established in all coronaviruses. They also determined that the region that encodes a gene called ORF3a also encodes an additional gene, which they name ORF3c.
Sep 20, 2019 · In the case of DENV-1 the 3′ UTR is ~470 nucleotides long, 450 nucleotides for DENV-2, 430 nucleotides for DENV-3, and the shortest is for DENV-4 with 385 nucleotides 3′ UTR can be divided in three domains (Proutski et al., 1997, Rauscher et al., 1997). Domain I is located immediately after the stop codon of NS5 and is considered the most ...
- Amudhan Murugesan, Mythreyee Manoharan
- 2020
- 10.1016/B978-0-12-819400-3.00016-8
May 2, 2024 · Figure 1.DENV serotypes 1–4 circulation in Nicaragua during 1998–2022. Data on dengue cases with serotype information available were obtained from the Nicaragua Dengue Surveillance Program; many more cases were confirmed via serology that are not included here because the serotype is unknown.
Oct 20, 2022 · We revealed the DENV-4 genetic factors that may lead to its predominance in the 2019 Jember dengue outbreak. A combination of selection pressure and mutational genetic changes may contribute to the DENV-4 predominance in East Java, Indonesia. The possible intra-serotype recombination events involving the non-structural protein 5 (NS5) gene were ...
Apr 23, 2021 · More than 1.2 million coronavirus genome sequences from 172 countries and territories have now been shared on a popular online data platform, which is a testament to the hard work of researchers ...
