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Oct 5, 2022 · Dengue virus infection. Picture 2. Headache, eye pain (ie, pain with eye movement), and joint pain occur in 60 to 70 percent of cases [ 24 ]. Rash occurs in approximately half of cases; it is more common during primary infection than secondary infection.
- Abstract
- Clinical Diagnosis
- Laboratory Diagnosis
- Future Tests
- Conclusions
- Notes
Dengue virus (DENV) infection is responsible for the most significant mosquito-borne viral disease in the world today. Like other flaviviruses, its genome comprises a single strand of positive-sense RNA encoding 3 structural and 7 nonstructural (NS) proteins . Unlike the other flaviviruses, there are 4 serotypes, referred to as DENV1–4, that are ge...
Clinical diagnosis of dengue can be challenging, depending largely on what stage in the infection process a patient presents. Depending on the geographic region of the world, there can be a number of disease-causing pathogens or disease states that can mimic the disease spectrum arising from dengue infection (Supplementary Table 1). In the early st...
Biomarkers that have been targeted for diagnosis include the virus itself (virus isolation in culture or mosquitoes or the direct detection of viral genomic RNA), viral products (capture and detection of the secreted NS1 protein), or the host immune response to virus infection (through measurement of virus-specific immunoglobulin M [IgM] and immuno...
There are many new approaches for rapid dengue diagnosis currently under development. These include micro/paper fluidics, in vivo micropatches [S74], isothermal PCR , and electrochemical [S75, S76] and piezoelectric [S77] detection. All of these technologies are in the early stage of development, requiring continued refinement to make them practica...
Early and accurate laboratory diagnosis of DENV infection is critical to effective patient management. While we already have the tools that allow us to reliably determine if a patient is suffering from dengue infection (Table 1 summarizes the diagnostic methods available, and a representative diagnostic algorithm is shown in Figure 3), we are still...
Acknowledgments.We thank Professor Cameron Simmons for his critical reading of this manuscript. Financial support.This work was in part supported by the National Health and Medical Research Council of Australia and the Queensland State Government (Accelerate Fellowship to DAM). Potential conflicts of interest.P. R. Y. has been a consultant to the b...
- David A. Muller, Alexandra C. I. Depelsenaire, Paul R. Young
- 2017
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Nov 24, 2020 · The disease spectrum ranges from asymptomatic infection and moderate febrile illness (dengue fever) to more serious manifestations such as dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) . The most severe clinical syndrome can manifest in the form of dengue shock syndrome (DSS), which also includes coagulation abnormalities ...
- Puneet Bhatt, Sasidharan Pillai Sabeena, Muralidhar Varma, Govindakarnavar Arunkumar, Govindakarnava...
- 10.1007/s00284-020-02284-w
- 2021
- Curr Microbiol. 2021; 78(1): 17-32.
Oct 1, 2023 · Abstract. Dengue is caused by the dengue virus (DENVs) infection and clinical manifestations include dengue fever (DF), dengue hemorrhagic fever (DHF), or dengue shock syndrome (DSS). Due to a lack of antiviral drugs and effective vaccines, several therapeutic and control strategies have been proposed. A systemic literature review was conducted ...
Feb 24, 2023 · This review aims to summarize epidemiology, biology, pathogenesis, clinical manifestations, and diagnosis of dengue virus infection and its trend in Ethiopia. It may help countries, where dengue fever is not yet on the public health list-like Ethiopia to alert healthcare workers to consider the disease for diagnosis and treatment.
- Biruk Zerfu, Tesfu Kassa, Mengistu Legesse
- Trop Med Health. 2023; 51: 11.
- 10.1186/s41182-023-00504-0
- 2023
Laboratory diagnosis methods for confirming dengue virus infection may involve detection of the virus, viral nucleic acid, antigens or antibodies, or a combination of these techniques. After the onset of illness, the virus can be detected in serum, plasma, circulating blood cells and other tissues for 4–5 days.
Aug 18, 2016 · This Primer provides a general overview on dengue, covering epidemiology, control, disease mechanisms, diagnosis, treatment and research priorities. Infection with any one of the four dengue virus ...
