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Single-stranded
- The Dengue virus, roughly spherical in shape, is an enveloped single-stranded positive-sense RNA virus with an icosahedral nucleocapsid covered by the lipid bilayer.
www.ncbi.nlm.nih.gov › pmc › articlesDengue Virus Infection: A Tale of Viral Exploitations and ...
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Like other viruses, the dengue virus is a microscopic structure that can only replicate inside a host organism. The four closely related dengue viruses — DEN-1, DEN-2, DEN-3, and DEN-4 —...
Sep 30, 2021 · The Dengue virus, roughly spherical in shape, is an enveloped single-stranded positive-sense RNA virus with an icosahedral nucleocapsid covered by the lipid bilayer. The 11 kb long DENV genome can function as mRNA, and, similar to that in eukaryotes, there are untranslated regions (UTRs) at both the 5′ and 3′ end flanking the open reading ...
- Nikita Nanaware, Anwesha Banerjee, Satarupa Mullick Bagchi, Parikshit Bagchi, Anupam Mukherjee
- 10.3390/v13101967
- 2021
- Viruses. 2021 Oct; 13(10): 1967.
Apr 14, 2022 · A 70 nt stem–loop RNA structure (called SLA), found at the 5′-end of the genome of all flaviviruses, functions as the promoter for viral replication. This highly conserved structure interacts with the viral polymerase NS5 to initiate RNA synthesis.
The dengue virus genome is a single strand of RNA. It is referred to as positive-sense RNA because it can be directly translated into proteins. The viral genome encodes ten genes (Figure 2).
After infecting a host cell, the dengue virus hijacks the host cell's machinery to replicate the viral RNA genome and viral proteins. Newly synthesized dengue viruses can go on to...
Jul 20, 2023 · However, our comprehension of the molecular mechanisms by which these viruses replicate is limited due to the lack of structural information. The DENV genome is a 10- to 11-kb-long positive-sense (+) single-stranded (ss) RNA with a 5′ cap (m 7 GpppAm) structure.
Dengue virus (DENV) is a single-stranded, positive-sense, enveloped RNA virus in the Flaviviridae family. DENV infection is the leading cause of mosquito-borne viral disease in humans (6, 7). The four major DENV serotypes share about 70% nucleotide identity but are antigenically distinct (8, 9).
