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Jan 31, 2018 · As discussed, infections or inflammation cause alterations in the expression levels and activities of various forms of P450 in the liver, as well as in other extrahepatic tissues such as kidney and brain . However, in most cases, the activity of CYPs is inhibited.
- Elisavet Stavropoulou, Gratiela G Pircalabioru, Eugenia Bezirtzoglou
- 10.3389/fimmu.2018.00089
- 2018
- Front Immunol. 2018; 9: 89.
Mar 8, 2019 · P450 families, namely CYP105, CYP107, CYP161, and CYP183, which are highly populated in Streptomyces species compared to mycobacterial species (Fig. 5B and C), were found to be involved in ...
- Louisa Moshoeshoe Senate, Martin Phalane Tjatji, Kayla Pillay, Wanping Chen, Ntokozo Minenhle Zondo,...
- 2019
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Oct 8, 2014 · CYP105s are predominantly found in bacteria belonging to the phylum Actinobacteria and the order Actinomycetales, with the exception of CYP105T1 which is found in Burkholderia fungorum, in the phylum Proteobacteria (based on those proteins named in the P450 nomenclature system at http://drnelson.uthsc.edu/bacterial.P450s.2011.htm).
Jan 31, 2018 · Cytochromes P450 (CYPs) are enzymes that oxidize substances using iron and are able to metabolize a large variety of xenobiotic substances. CYP enzymes are linked to a wide array of reactions including and O-dealkylation, S-oxidation, epoxidation, and hydroxylation.
- Elisavet Stavropoulou, Gratiela G Pircalabioru, Eugenia Bezirtzoglou
- 2018
In streptomycetes, they are predominantly associated with secondary metabolite biosynthetic pathways or with xenobiotic catabolism. Homologues of one family, CYP105, have been found in all Streptomyces species thus far sequenced. This review looks at the diverse biological functions of CYP105s and the biosynthetic/catabolic pathways they are ...
Feb 2, 2013 · Many bacteria contain no cytochromes P450; this is true of Eubacteria, for example Escherichia coli, and the Archaea, and early researchers may be forgiven for not anticipating any or few to be discovered. However, bacterial CYPs have also increased substantially in family numbers, with more than 1000 named (CYP101 upwards).
to assign proteins within the same P450 family (e.g. CYP105), and 55% identity is required for assignment within the same subfamily (e.g. CYP105A). In bacteria, the occurrence of P450s is highly variable. While the Escherichia coli genome has no identified P450s, many other species contain multiple P450 homo-logues.
