- The Sepsis-3 consensus defined adult sepsis as a “life-threatening organ dysfunction caused by a dysregulated host response to infection”. 3 The Paediatric sepsis definition is under development by the International Pediatric Sepsis Definition Taskforce and has found strong associations of organ dysfunction markers linked with clinical outcomes suitable for inclusion in the validation phase of the definition. 4 However neonatal sepsis definitions are not aligned with those in adults and children...
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What is the international consensus on the definition of neonatal sepsis?
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Though intended to facilitate study of this important disease in all children, the pediatric consensus definitions for sepsis are not accurate for term neonates and were not created for preterm neonates. Thus, consensus definitions for sepsis in term and preterm infants are needed so that future epidemiologic studies and trials of diagnostic and therapeutic interventions can be interpreted and implemented.
- James L. Wynn, Hector R. Wong, Hector R. Wong, Thomas P. Shanley, Matthew J. Bizzarro, Lisa Saiman, ...
The pediatric consensus definition for sepsis, established in 2005 to support the trial of activated protein C for the treatment of pediatric sepsis, was intended for all children (<18 years old) and including term (≥37 weeks completed gestation) neonates . Preterm neonates (<37 weeks completed gestation) were specifically excluded from the ...
- James L. Wynn
Mar 19, 2020 · In addition to the lack of an internationally accepted consensus definition of neonatal sepsis, there are no definitions associated with long-term outcomes. This lack hinders ongoing collaborative...
- Eleanor J. Molloy, James L. Wynn, Joseph Bliss, Joyce M. Koenig, Fleur M. Keij, Matt McGovern, Helmu...
Recent findings: Pediatric consensus definitions for sepsis are not accurate in term infants and are not appropriate for preterm infants. In contrast to the defined multistage criteria for other devastating diseases encountered in the NICU (e.g., bronchopulmonary dysplasia), there is significant variability in the criteria used by investigators ...
- James L. Wynn