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  1. Feb 01, 2017 · Deficiencies related to the definition in sepsis 1. Although the 1991 North American consensus definition considers the combination of infection and SIRS response as sepsis, a sepsis-like clinical picture may be observed without infection. The current significance of inflammation is non-specific and may manifest in many conditions.

  2. Aug 01, 2014 · Sepsis, by definition, is caused by an infection; not surprisingly, there is a consensus that an anti-infectious agent must be given as early as possible to all patients with sepsis . Over the past 20 years, a large number of RCTs have attempted to control the systemic inflammatory storm characterizing sepsis with little success.

  3. Blood cultures are recommended for evaluation of febrile neonates younger than one month because occult bacteremia is more common in this age group. 11, 14, 22 For non–ill-appearing infants one ...

  4. Jul 15, 2021 · Acute kidney injury (AKI) is defined by a sudden loss of excretory kidney function. AKI is part of a range of conditions summarized as acute kidney diseases and disorders (AKD), in which slow ...

  5. Alternatively, it may result from direct loss of bicarbonate from the kidney or gut (eg, during chronic diarrhoea). In all forms of metabolic acidosis there is a low blood bicarbonate level, either due to loss of bicarbonate or due to buffering of excess acid by bicarbonate which is excreted as CO 2. A common cause of metabolic acidosis is ...

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