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Mar 21, 2019 · Abstract. There has been a significant evolution in the definition and management of sepsis over the last three decades. This is driven in part due to the advances made in our understanding of its pathophysiology. There is evidence to show that the manifestations of sepsis can no longer be attributed only to the infectious agent and the immune ...
In contrast to the defined multistage criteria for other devastating diseases encountered in the NICU (e.g., bronchopulmonary dysplasia), there is significant variability in the criteria used by investigators to substantiate the diagnosis of neonatal sepsis. Summary: The lack of an accepted consensus definition for neonatal sepsis impedes our ...
Mar 19, 2020 · Overview of neonatal sepsis and definitions. Sepsis represents a major contributor to global mortality and has been declared as a priority by the WHO. 1 The highest sepsis incidence across all age ...
May 25, 2022 · Each year, an estimated 25 million neonates, children, and adolescents suffer from sepsis, leading to over 3 million deaths globally. 1 Yet, controversy surrounds the attempts to operationalize the definition of sepsis in pediatric age groups and poses a major obstacle to implementation of the World Health Organization (WHO) resolution designating sepsis as a global health priority. 2 Children ...
This Viewpoint makes the case that the importance of early detection of sepsis and the need for rapid antibiotics in patients with definite infection and possible septic shock has likely led to overuse of antibiotics in patients who might not need them, and argues for testing to confirm infection in non-shock patients in place of rapid empirical antimicrobial treatment.
Oct 11, 2017 · Consensus definitions for sepsis align investigators and are used in clinical practice and investigations for all patients with one startling exception: patients cared for in the neonatal ...
Jan 20, 2024 · Neonatal sepsis is a leading disease in neonatal intensive care units (NICU) and remains the second cause of death among infants ≤28 days in developing countries. 1 Two-thirds of these deaths ...
