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  1. Aug 8, 2019 · There is increasing recognition that a validated consensus definition of neonatal sepsis is a critical step to improve identification and treatment of septic neonates and improve related outcomes ...

    • Matthew McGovern, Eric Giannoni, Helmut Kuester, Mark A Turner, Agnes van den Hoogen, Joseph M Bliss...
    • 2020
  2. The adult and pediatric consensus definitions sepsis stipulate that evidence of SIRS be present as a prerequisite to meeting criteria for sepsis. SIRS requires either 1) abnormal WBC count [total WBC increased or decreased for age -or- >10% immature neutrophils] or 2) abnormal core temperature (>38.5° or <36°C) ( 41 ).

    • James L. Wynn
    • 2016
  3. Sepsis remains a leading cause of morbidity and mortality in the neonatal population, and at present, there is no unified definition of neonatal sepsis. Existing consensus sepsis definitions within paediatrics are not suited for use in the NICU and do not address sepsis in the premature population. Many neonatal research and surveillance ...

    • Matthew McGovern, Eric Giannoni, Helmut Kuester, Mark A Turner, Agnes van den Hoogen, Joseph M Bliss...
    • 2020
  4. Mar 19, 2020 · Overview of neonatal sepsis and definitions. Sepsis represents a major contributor to global mortality and has been declared as a priority by the WHO. 1 The highest sepsis incidence across all age ...

    • Eleanor J. Molloy, James L. Wynn, Joseph Bliss, Joyce M. Koenig, Fleur M. Keij, Matt McGovern, Helmu...
    • 2020
  5. Jun 11, 2020 · The 1991 consensus conference on sepsis , and subsequent adult and pediatric sepsis definitions have operationalized the disease definition using systemic inflammatory response syndrome (SIRS) in the presence of presumed or proven infection as a requirement to meet criteria for sepsis, severe sepsis, or septic shock (9–11). SIRS was ...

    • Kusum Menon, Luregn J Schlapbach, Luregn J Schlapbach, Samuel Akech, Andrew Argent, Kathleen Chiotos...
    • 10.1097/CCE.0000000000000123
    • 2020
    • Crit Care Explor. 2020 Jun; 2(6): e0123.
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  7. May 25, 2022 · Each year, an estimated 25 million neonates, children, and adolescents suffer from sepsis, leading to over 3 million deaths globally. 1 Yet, controversy surrounds the attempts to operationalize the definition of sepsis in pediatric age groups and poses a major obstacle to implementation of the World Health Organization (WHO) resolution designating sepsis as a global health priority. 2 Children ...

  8. Sepsis represents a major contributor to global mortality and has been declared as a priority by the WHO.1 The highest sepsis incidence across all age groups is found in neonates affecting an ...