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Nov 15, 2022 · Objective. Identify VWD causing HBM in patients with IDA. Materials and Methods. Retrospective databased study from 2017 to 2021 of 292 women with IDA due HMB referred to our Institution. HMB was not related to systemic disease, hormonal disorders, renal or hepatic disease.
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Many people with von Willebrand disease don't know it because the signs are mild or absent. The most common sign of the condition is abnormal bleeding.
There are three main types of the disease. The amount of bleeding varies from one person to another, depending on the type and severity of the disease.
If you have von Willebrand disease, you might have:
•Excessive bleeding from an injury or after surgery or dental work
•Frequent nosebleeds that don't stop within 10 minutes
•Heavy or long menstrual bleeding
Contact your doctor if you have bleeding that lasts a long time or is hard to stop.
Request an appointment
The usual cause of von Willebrand disease is an inherited abnormal gene that controls von Willebrand factor — a protein that plays a key role in blood clotting.
When you have low levels of this protein or it doesn't work as it should, small blood cells called platelets cannot stick together properly nor attach themselves normally to the blood vessel walls when an injury has occurred. This interferes with the clotting process and can sometimes cause uncontrolled bleeding.
Many people with von Willebrand disease also have low levels of factor VIII, another protein that helps in clotting.
Factor VIII is involved in another inherited clotting disorder called hemophilia. But unlike hemophilia, which mainly affects males, von Willebrand disease affects males and females and is usually milder.
The main risk factor for von Willebrand disease is having a family history of it. Parents pass the gene for the disease to their children. Rarely, the disease skips generations.
The disease is usually an "autosomal dominant inherited" disorder, which means you need a mutated gene from only one parent to get the disease. If you have the gene for von Willebrand disease, you have a 50% chance of transmitting this gene to your children.
Rarely, von Willebrand disease can cause uncontrollable bleeding, which can be life-threatening. Other complications of von Willebrand disease can include:
•Anemia. Heavy menstrual bleeding can cause iron deficiency anemia.
If you plan to have children and have a family history of von Willebrand disease, consider genetic counseling. If you carry the gene for von Willebrand disease, you can pass it on to your offspring, even if you don't have symptoms.
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By Mayo Clinic Staff
Oct 26, 2021
1.Von Willebrand disease. Centers for Disease Control and Prevention. https://www.cdc.gov/ncbddd/vwd/facts.html. Accessed Aug. 26, 2021.
2.AskMayoExpert. Von Willebrand disease. Mayo Clinic; 2021.
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People also ask
Can von Willebrand disease cause uncontrollable bleeding?
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How is von Willebrand disease (vWD) diagnosed?
Dec 6, 2019 · Laboratory evaluation showed mild anemia with a hemoglobin of 9.6 g/dL, normal platelet count, and normal white count. von Willebrand factor antigen (VWF:Ag) was 36 IU/dL, von Willebrand factor (VWF):RCo activity was <10 IU/dL, and von Willebrand factor collagen binding activity (VWF:CB) activity was also low at 15 IU/dL.
- Ruchika Sharma, Sandra L. Haberichter
- 10.1182/hematology.2019000064
- 2019
- 2019/12/12
May 25, 2022 · Approach to the adult with a suspected bleeding disorder. Pathophysiology of von Willebrand disease. Clinical presentation and diagnosis of von Willebrand disease. von Willebrand disease (VWD): Treatment of major bleeding and major surgery.
Dec 9, 2022 · Von Willebrand disease (VWD), the most common inherited bleeding disorder (IBD), disproportionately affects females, given the hemostatic challenges they may encounter throughout their lifetimes. Despite this, research about VWD remains grossly underrepresented, particularly compared to hemophilia, which is historically diagnosed in males.
Aug 28, 2023 · Von Willebrand disease is a bleeding disorder caused by the qualitative or quantitative deficiency of the pro-von Willebrand factor. Affected people may complain of excessive bruising, prolonged bleeding from mucosal surfaces, and prolonged bleeding after minor trauma.
Synopsis. Von Willebrand disease (VWD) is a common bleeding disorder, affecting males and females equally, that often manifests in mucosal bleeding. VWD can be secondary to a quantitative (Type 1 and Type 3) or qualitative (Type 2) defects in Von Willebrand factor.
