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  1. Dec 6, 2019 · Surgical procedures represent a serious hemostatic challenge for patients with von Willebrand disease (VWD), and careful perioperative management is required to minimize bleeding risk. Risk stratification includes not only the nature of the surgery to be performed but the baseline plasma von Willebrand factor (VWF) levels, bleeding history, and ...

    • James S. O’Donnell, Michelle Lavin
    • 2019
  2. Jan 1, 2022 · The management of patients with VWD who are undergoing surgeries is crucial to prevent bleeding complications. We systematically summarized the evidence on the management of patients with VWD who are undergoing major and minor surgeries to support the development of practice guidelines.

    • 10.1182/bloodadvances.2021005666
    • 2022/01/01
    • Blood Adv. 2022 Jan 11; 6(1): 121-128.
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  4. Dec 3, 2015 · Abstract. Objectives: von Willebrand disease (VWD) is the most common hereditary bleeding disorder. This study reviews the management of perioperative anticoagulation in patients with VWD undergoing surgical procedures.

    • Mario Von Depka, Carsten Detering, Stefanie Döpke, Mahnaz Ekhlasi-Hundrieser
    • 2015
  5. ciency of von Willebrand factor. With type 1, all multimers are present and in same proportion, but reduced. Factor VIII, von Willebrand factor activity and von Willebrand factor antigen can be reduced or around the normal range. Type one von Willebrand disease is the least dangerous, but will require test of the clotting factors prior to any ...

  6. Sep 18, 2015 · We report the case of a 42-year-old woman, with type I von Willebrand disease, who underwent off-pump coronary artery bypass grafting. Beating heart surgery associated with an adequate replacement of von Willebrand factor and factor VIII levels were chosen to prevent bleeding disorders.

    • Federica Jiritano, Lucia Cristodoro, Egidio Bevacqua, Emanuele Malta, Pasquale Mastroroberto
    • 2015
  7. Mar 1, 2008 · Von Willebrand disease (vWD), a hemorrhagic disorder mimicking a defect in platelet function, is the most commonly inherited coagulopathy, resulting in a deficiency that may prolong bleeding time and increase risk for major bleeding complications during surgery.

  8. Sep 13, 2016 · VWD is caused by a deficiency or dysfunction of von Willebrand factor (VWF), a plasma protein that mediates the i... Von Willebrand disease – the ‘Dos’ and ‘Don'ts’ in surgery - Miesbach - 2017 - European Journal of Haematology - Wiley Online Library

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