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  1. Dec 19, 2022 · Research has shown that esketamine can significantly reduce depression symptoms — relief that can last weeks after treatment ends. Though they’re far from perfect treatments, ketamine and esketamine mark a breakthrough, as they’re the only fast-acting antidepressants available.

  2. Apr 15, 2024 · In 2019, the Food and Drug Administration (FDA) approved esketamine as a treatment for forms of depression that haven’t improved with standard antidepressants (like citalopram/Celexa or...

  3. Nov 1, 2022 · Ketamine offers a new, fast-acting approach to relieving treatment-resistant depression. Learn the research-backed benefits and how to try it.

  4. Dec 29, 2023 · Is ketamine a treatment for depression? What are the risks? Learn about the uses, benefits, and side effects of ketamine.

  5. May 22, 2019 · Why is ketamine exciting for treating depression? If a person responds to ketamine, it can rapidly reduce suicidality (life-threatening thoughts and acts) and relieve other serious symptoms of depression. Ketamine also can be effective for treating depression combined with anxiety.

  6. Mar 9, 2022 · In 2019. the FDA approved the first new medication for major depression in decades. The drug is a nasal spray called esketamine, derived from ketamine—an anesthetic that has made waves for its surprising antidepressant effect. Our Yale psychiatrists discuss its benefits and limitations.

  7. Apr 15, 2022 · Initial studies found that a single subanesthetic-dose IV ketamine infusion rapidly (within one day) improved depressive symptoms in individuals with MDD and bipolar depression, with antidepressant effects lasting three to seven days.

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