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      • Blood, cerebrospinal fluid, and urine cultures always should be obtained when late-onset sepsis is suspected. Blood culture, the gold standard in diagnosis, is highly sensitive but needs up to 48 hours to detect microbial growth. Various cytokines have been investigated as early markers of infection, but results are not uniform.
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    What is/are the earliest predictor(s) of neonatal sepsis?

    What are the signs and symptoms of neonatal sepsis?

    What are the differential diagnoses for neonatal sepsis?

    What are the symptoms of early sepsis?

  2. Specific guidelines for neonates are often lacking and our NICU is not compliant with late onset sepsis (LOS) guidelines. Objective: By January 2019, there will be >75% compliance with our LOS bundle for any infant admitted to Tampa General Hospital's (TGH) NICU undergoing a LOS evaluation at >72 h of life.

    • V Lamba, S D'souza, C Carafa, A Zepf, C L Bassel, M Gutierrez, M Balakrishnan
    • 5
    • 2020
  3. Nov 25, 2014 · A prompt cessation of antibiotics is generally warranted if blood culture yields negative results after 36–48 h, and the infant shows no subsequent clinical evidence of sepsis or other neonatal infections. 63 66 Although appropriately cautious, this practice still leads to unnecessary antibiotic exposure among many infants, since blood cultures are positive in only 5%–10% of suspected cases. 17 21 It is alerting that antibiotics are overused in patients who did not actually develop LOS ...

    • Ying Dong, Christian P Speer
    • 349
    • 2015
  4. Abstract. Late onset neonatal sepsis (LOS) has a high mortality and the optimal management is poorly defined. We aimed to evaluate new expert panel-derived criteria to define LOS and characterize the current management and antibiotic susceptibility of LOS-causing organisms in Europe. A prospective observational study enrolled infants aged 4 to 90 days in five European countries.

    • Irja Lutsar, Corine Chazallon, Francesca Ippolita Calò Carducci, Ursula Trafojer, Ben Abdelkader, Vi...
    • 54
    • 2014
  5. Oct 10, 2021 · Neonatal sepsis is divided into two groups based on the time of presentation after birth: early-onset sepsis (EOS) and late-onset sepsis (LOS). EOS refers to sepsis in neonates at or before 72 hours of life ( some experts use seven days), and LOS is defined as sepsis occurring at or after 72 hours of life .

  6. Aug 01, 2010 · Late-onset sepsis significantly increases preterm infant mortality and the risk of cerebral lesions and neurosensory sequelae, including developmental difficulties and cerebral palsy. Early diagnosis of late-onset sepsis contributes to improved neonatal prognosis, but the outcome remains far from satisfactory.

    • Maria Regina Bentlin, Lígia Maria Suppo de Souza Rugolo
    • 15
    • 2010
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