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  1. Nov 1, 2022 · Neonatal late-onset sepsis (LOS) continues to threaten morbidity and mortality in the NICU and poses ongoing diagnostic and therapeutic challenges. Early recognition of clinical signs, rapid evaluation, and prompt initiation of treatment are critical to prevent life-threatening deterioration.

  2. Sep 29, 2022 · Late-onset sepsis (LOS) usually occurs via the transmission of pathogens from the surrounding environment after delivery, such as contact from healthcare workers or caregivers. A percentage ofLOS may also be caused by a late manifestation of vertically transmitted infection.

    • Meenakshi Singh, Mahdi Alsaleem, Cory P. Gray
    • 2022/09/29
  3. Aug 1, 2021 · This guideline addresses the evaluation and management of well-appearing, term infants, 8 to 60 days of age, with fever ≥38.0°C. Exclusions are noted. After a commissioned evidence-based review by the Agency for Healthcare Research and Quality, an additional extensive and ongoing review of the literature, and supplemental data from published, peer-reviewed studies provided by active ...

  4. sepsis in neonates with suspected late-onset sepsis Weak Moderate b. However, in level-2 neonatal units with no facilities for blood culture, the group suggests using serum CRP as a screening tool to rule out sepsis in neonates with a low probability of late-onset sepsis (for example, neonates with apnea, feed intolerance, or fast breathing)

  5. May 8, 2021 · Therefore, there is a need for such a review assessing the effects of different antibiotic regimens for lateonset neonatal sepsis. Study characteristics. The evidence is current to March 2021. We included five trials randomising 580 participants. The five trials compared five different antibiotic regimens.

    • Steven Kwasi Korang, Sanam Safi, Chiara Nava, Adrienne Gordon, Munish Gupta, Gorm Greisen, Ulrik Lau...
    • 10.1002/14651858.CD013836.pub2
    • 2021
    • 2021
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  7. Oct 18, 2023 · Sepsis is an important cause of morbidity and mortality among newborn infants. Although the incidence of sepsis in term and late preterm neonates is low, the potential for serious adverse outcomes is of such great consequence that caregivers should have a low threshold for evaluation and treatment for possible sepsis in neonates.

  8. Nov 11, 2022 · 10.1542/6312701839112Video AbstractPEDS-VA_2022-0588136312701839112OBJECTIVES. To determine the epidemiology, microbiology, and associated outcomes of late-onset sepsis among very preterm infants using a large and nationally representative cohort of NICUs across the United States.METHODS. Prospective observational study of very preterm infants born 401 to 1500 g and/or 22 to 29 weeks ...