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  1. The CDC recommends two-step testing, sometimes referred to as a two-tiered test, for Lyme disease. You will need to go to a lab to have blood drawn. It takes a few days to get results. If the first test comes back positive or unclear, the lab will do the second blood test.

  2. Serological testing for Lyme disease primarily uses US Food and Drug Administration (FDA)–cleared tests for immunoglobulin M (IgM) or immunoglobulin G (IgG) antibodies to B burgdorferi, guided by symptoms and the timeline of exposure. 2,15,16 Two to 4 weeks following the tick bite, positive antibody results for IgM and negative results for IgG i...

  3. Lyme disease diagnoses and disease management would benefit from validated diagnostic tests that directly measure the infection such as a culture, PCR test, or antigen detection tests. Direct tests are vital to the management of other infectious diseases such as HIV, hepatitis C, strep, and COVID-19, but have not yet become widely available for ...

  4. Feb 10, 2023 · Most people who get Lyme disease don't remember having a tick bite. And many symptoms of Lyme disease relate to other conditions. See your health care provider if you have Lyme disease symptoms.

  5. Lyme disease tests look for signs of infection in a sample of your blood or cerebrospinal fluid (CSF). CSF is a clear liquid that flows in and around your brain and spinal cord. The test checks your sample for antibodies that your immune system makes to fight the bacteria that cause Lyme disease.

  6. Serology is the most accurate testing method for Lyme disease, despite false negatives that can occur with acute illness. Antibody testing is universally recommended over polymerase chain...

  7. Lyme disease is a clinical diagnosis—based on your medical history, symptoms and exposure to ticks. Because the typical Lyme disease diagnostic tests are so insensitive, a negative test result does not mean you don’t have Lyme. There are many reasons why someone who actually has Lyme may have a negative test result.

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