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What is Marburg virus disease?
Can Marburg virus cause MVD?
What is the fatality rate of Marburg virus disease (MVD)?
How is Marburg virus disease diagnosed?
Marburg virus disease (MVD) is a rare but severe hemorrhagic fever caused by the Marburg virus, a filovirus that belongs to the same family as Ebola. Learn about the symptoms, risk of exposure, diagnosis, treatment and prevention of MVD from the CDC, the leading source of information and resources on this topic.
- Signs and Symptoms
Clinical diagnosis of Marburg virus disease (MVD) can be...
- Transmission
It is unknown how Marburg virus or Ravn virus, collectively...
- Outbreaks
Timen A, Koopmans M, Vossen A, et al. Response to Imported...
- Risk of Exposure
People sick with Marburg virus disease (MVD); or; Non-human...
- Screening Patients
Illness typically progresses from “dry” symptoms (fever,...
- About Marburg Virus Disease
Marburg virus disease (MVD) is a rare but severe hemorrhagic...
- Signs and Symptoms
- Transmission
- Symptoms of Marburg Virus Disease
- Diagnosis
- Treatment and Vaccines
- Marburg Virus in Animals
- Prevention and Control
- Controlling Infection in Healthcare Settings
- Marburg Viral Persistence in in People Recovering from Marburg Virus Disease
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Initially, human MVD infection results from prolonged exposure to mines or caves inhabited by Rousettus bat colonies. Marburg spreads through human-to-human transmission via direct contact (through broken skin or mucous membranes) with the blood, secretions, organs or other bodily fluids of infected people, and with surfaces and materials (e.g. bed...
The incubation period (interval from infection to onset of symptoms) varies from 2 to 21 days. Illness caused by Marburg virus begins abruptly, with high fever, severe headache and severe malaise. Muscle aches and pains are a common feature. Severe watery diarrhoea, abdominal pain and cramping, nausea and vomiting can begin on the third day. Diarrh...
It can be difficult to clinically distinguish MVD from other infectious diseases such as malaria, typhoid fever, shigellosis, meningitis and other viral haemorrhagic fevers. Confirmation that symptoms are caused by Marburg virus infection are made using the following diagnostic methods: 1. antibody-capture enzyme-linked immunosorbent assay (ELISA) ...
Currently there are no vaccines or antiviral treatments approved for MVD. However, supportive care – rehydration with oral or intravenous fluids – and treatment of specific symptoms, improves survival. There are monoclonal antibodies (mAbs) under development and antivirals e.g. Remdesivir and Favipiravir that have been used in clinical studies for ...
Rousettus aegyptiacusbats are considered natural hosts for Marburg virus. There is no apparent disease in the fruit bats. As a result, the geographic distribution of Marburg virus may overlap with the range of Rousettus bats. African green monkeys (Cercopithecus aethiops) imported from Uganda were the source of infection for humans during the first...
Good outbreak control relies on using a range of interventions, namely case management, surveillance and contact tracing, a good laboratory service, safe and dignified burials, and social mobilization. Community engagement is key to successfully controlling outbreaks. Raising awareness of risk factors for Marburg infection and protective measures t...
Healthcare workers should always take standard precautions when caring for patients, regardless of their presumed diagnosis. These include basic hand hygiene, respiratory hygiene, use of personal protective equipment (to block splashes or other contact with infected materials), safe injection practices and safe and dignified burial practices. Healt...
Marburg virus is known to persist in immune-privileged sites in some people who have recovered from Marburg virus disease. These sites include the testicles and the inside of the eye. 1. In women who have been infected while pregnant, the virus persists in the placenta, amniotic fluid and foetus. 2. In women who have been infected while breastfeedi...
WHO aims to prevent Marburg outbreaks by maintaining surveillance for Marburg virus disease and supporting at-risk countries to develop preparedness plans. The following document provides overall guidance for control of Ebola and Marburg virus outbreaks: 1. Ebola and Marburg virus disease epidemics: preparedness, alert, control, and evaluation When...
Marburg virus disease (MVD) is a severe, often fatal illness caused by a filovirus that spreads among humans through contact with blood, secretions or other fluids of infected people. It can be transmitted from fruit bats and has a case fatality rate of up to 88%. Symptoms include high fever, severe headache, diarrhoea, abdominal pain and bleeding. Treatment is supportive care and rehydration. There are no licensed vaccines or antiviral treatments.
Jun 20, 2023 · What causes Marburg virus disease? Two related viruses, Marburg virus (MARV) and Ravn virus (RAVV) cause MVD. They’re also related to the virus that causes Ebola. Marburg virus disease is a viral hemorrhagic fever, which can damage your blood vessels and cause severe bleeding. How does Marburg virus disease spread?
Feb 13, 2023 · Marburg hemorrhagic fever is a severe and highly fatal disease caused by a virus from the same family as the one that causes Ebola hemorrhagic fever. Both diseases are rare, but can cause dramatic outbreaks with high fatality. There is currently no specific treatment or vaccine. Two cases of Marburg virus infection were reported in Uganda.
Marburg virus disease (MVD; formerly Marburg hemorrhagic fever) is a viral hemorrhagic fever in human and non-human primates caused by either of the two Marburgviruses: Marburg virus (MARV) and Ravn virus (RAVV). Its clinical symptoms are very similar to those of Ebola virus disease (EVD).
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