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   What physiology & best practice guidelines are needed for sepsis?

   • It requires prompt recognition, appropriate antibiotics, careful hemodynamic support, and control of the source of infection. With the trend in management moving away from protocolized care in favor of appropriate usual care, an understanding of sepsis physiology and best practice guidelines is critical.

   Sepsis and septic shock: Guideline-based management

   www.ccjm.org/content/87/1/53

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   How early can sepsis be treated?

   • Research has shown, however, that if treatment is started within the first few hours from the time sepsis begins, the mortality rate from sepsis falls significantly. That makes early, aggressive treatment of sepsis crucial. If it is caught quickly, sepsis often can be managed effectively. — Dr.

   Mayo Clinic Q and A: Understanding sepsis and septic shock

   newsnetwork.mayoclinic.org/discussion/mayo-clinic-q-and-a-understanding-sepsis-and-septic-shock/

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   What can be done to treat severe sepsis & septic shock?

   • Inflammation and the blood microvascular system. Early goal-directed therapy in the treatment of severe sepsis and septic shock. Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. A randomized trial of protocol-based care for early septic shock. Trial of early, goal-directed resuscitation for septic shock.

   Rational Fluid Resuscitation in Sepsis for the Hospitalist

   www.mayoclinicproceedings.org/article/S0025-6196(21)00428-6/fulltext

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2. www.mayoclinic.org › diseases-conditions › sepsisSepsis - Diagnosis & treatment - Mayo Clinic

   www.mayoclinic.org › diseases-conditions › sepsis

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   Feb 10, 2023 · Treatment. Early, thorough treatment raises the likelihood of recovery. People who have sepsis need close monitoring and treatment in a hospital intensive care unit. This is because people with sepsis may need lifesaving measures to stabilize breathing and heart action.

   • Symptoms & Causes

     Most people recover from mild sepsis, but the mortality rate...

   • Doctors & Departments

     Learn more about the symptoms and treatment of sepsis, a...

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   • Liver Function Tests

     Overview. Liver function tests are blood tests used to help...

   • Mayo Clinic Q and A

     Mayo Clinic Q and A: Understanding sepsis and septic shock....

3. www.mayoclinicproceedings.org › article › S0025-6196Severe Sepsis and Septic Shock: Clinical Overview and Update ...

   www.mayoclinicproceedings.org › article › S0025-6196

   Nov 1, 2014 · Learning Objectives: On completion of reading this article, you should be able to (1) recognize patients with severe sepsis and septic shock to provide appropriate early-goal directed therapy, (2) define treatment goals within the first 6 hours for patients with severe sepsis and septic shock, and (3) describe the management strategies for ...

   • Author: Kelly A. Cawcutt, Steve G. Peters

   • Publish Year: 2014

4. www.ccjm.org › content › 87/1/53Sepsis and septic shock: Guideline-based management

   www.ccjm.org › content › 87/1/53

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   Jan 1, 2020 · This article reviews guidance on the diagnosis and management of sepsis and septic shock, with attention to maximizing adherence to best practice statements, and controversies in definitions, diagnostic criteria, and management.

   • Author: Siddharth Dugar, Chirag Choudhary, Abhijit Duggal

   • Publish Year: 2020

5. www.aafp.org › pubs › afpSepsis: Diagnosis and Management | AAFP

   www.aafp.org › pubs › afp

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   Apr 1, 2020 · The guidelines recommend the Sequential Organ Failure Assessment (original and quick versions) as an important tool for early diagnosis. Respiratory, gastrointestinal, genitourinary, and...

6. www.mayoclinicproceedings.org › article › S0025-6196Rational Fluid Resuscitation in Sepsis for the Hospitalist

   www.mayoclinicproceedings.org › article › S0025-6196

   Aug 5, 2021 · Current guidelines suggest a protocolized approach to fluid resuscitation in sepsis despite a lack of strong physiological or clinical evidence to support it. Both initial and ongoing fluid resuscitation requires careful consideration, as fluid overload has been shown to be associated with increased risk for mortality.