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Jul 31, 2023 · Mechanism of Action. As with other nitrates used to treat anginal chest pain, nitroglycerin converts to nitric oxide (NO) in the body. NO then activates the enzyme guanylyl cyclase, which converts guanosine triphosphate (GTP) to guanosine 3',5'-monophosphate (cGMP) in vascular smooth muscle and other tissues. cGMP then activates many protein kinase-dependent phosphorylations, which enhances ...
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Introduction. According to the American Heart Association,...
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Introduction. In this review, we detail the discovery of...
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Generic Name Nitroglycerin DrugBank Accession Number DB00727 Background. Nitroglycerin, also known as glyceryl trinitrate, 2 is an organic nitrate and a vasodilating agent 17 that was first discovered in 1847. 9 Originally used to dynamite, its antianginal effects were identified in the late 1860s after it produced headaches in factory workers while workers with angina pectoris or heart ...
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- Dosing: Adult
- Dosing: Pediatric
- Reconstitution
- Administration
Note:Nitronal IV solution has been discontinued in the US for more than 1 year. Note:Hemodynamic and antianginal tolerance often develop within 24 to 48 hours of continuous nitrate administration. Nitrate-free interval (10 to 12 hours/day) is recommended to avoid tolerance development; gradually decrease dose in patients receiving nitroglycerin for...
Note:Nitronal IV solution has been discontinued in the US for more than 1 year. Note: Continuous IV infusion dosing units vary by age (mcg/kg/minute or mcg/minute); extra precautions should be taken. Tolerance to the hemodynamic and antianginal effects can develop within 24 to 48 hours of continuous use. Nitrate-free interval (10 to 12 hours/day) i...
Nitronal (glyceryl trinitrate) 1 mg/mL (temporarily available in the US): To prepare a 100 mcg/mL solution: Withdraw 25 mL D5W from a 250 mL bottle of D5W and replace volume with 25 mg (25 mL) of Nitronal. To prepare a 200 mcg/mL solution: Withdraw 50 mL D5W from a 250 mL bottle of D5W and replace volume with 50 mg (50 mL) of Nitronal.
IV: Prepare in glass bottles, EXCEL or PAB containers. Adsorption occurs to soft plastic (eg, PVC); use administration sets intended for nitroglycerin. Avoid in-line IV filters that adsorb nitroglycerin. Administer via infusion pump. Intra-anal ointment: Using a finger covering (eg, plastic wrap, surgical glove, finger cot), place finger beside 1 i...
Nitroglycerin (medication) Nitroglycerin, also known as glyceryl trinitrate ( GTN ), is a vasodilator used for heart failure, high blood pressure ( hypertension ), anal fissures, painful periods, and to treat and prevent chest pain caused by decreased blood flow to the heart ( angina) or due to the recreational use of cocaine.
- C₃H₅N₃O₉
- sublingual, transdermal, by mouth, intravenous
- liver (rapid), red blood cells, vascular wall
- Nitrol, others
Jul 4, 2017 · Nitroglycerine and Angina. Article, see p 24. Nitroglycerin (NTG) was invented in 1847 and used for angina pectoris or heart failure since 1879 as reviewed by Asrress et al 1 in the current issue of Circulation. An extensive literature shows that NTG lowers blood pressure, vasodilates epicardial coronary arteries, and in experimental models ...
Jun 4, 2002 · In 1998, about 130 years after Alfred Nobel's invention of dynamite and the first observed clinical benefit of nitroglycerin, the Nobel Prize in Physiology or Medicine was awarded for “Nitric Oxide as a Signaling Molecule in the Cardiovascular System”. Despite these achievements, the precise molecular mechanism by which NO is generated from ...
