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Jul 31, 2023 · Nitroglycerin is a vasodilatory drug used primarily to provide relief from anginal chest pain. It is currently FDA approved for the acute relief of an attack or acute prophylaxis of angina pectoris secondary to coronary artery disease. Off-label, non-FDA-approved uses include treatment for hypertensive urgency/emergency, coronary artery spasm, angina secondary to cocaine use, congestive heart ...
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Introduction. According to the American Heart Association,...
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Introduction. In this review, we detail the discovery of...
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Generic Name Nitroglycerin DrugBank Accession Number DB00727 Background. Nitroglycerin, also known as glyceryl trinitrate, 2 is an organic nitrate and a vasodilating agent 17 that was first discovered in 1847. 9 Originally used to dynamite, its antianginal effects were identified in the late 1860s after it produced headaches in factory workers while workers with angina pectoris or heart ...
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Nitroglycerin (medication) Nitroglycerin, also known as glyceryl trinitrate ( GTN ), is a vasodilator used for heart failure, high blood pressure ( hypertension ), anal fissures, painful periods, and to treat and prevent chest pain caused by decreased blood flow to the heart ( angina) or due to the recreational use of cocaine.
- C₃H₅N₃O₉
- sublingual, transdermal, by mouth, intravenous
- liver (rapid), red blood cells, vascular wall
- Nitrol, others
Jul 28, 2021 · Overdose. An overdose of nitroglycerin may occur when a person uses PDE-5 inhibitors with nitroglycerin or uses too much nitroglycerin during an angina attack. Severe side effects that doctors ...
Descriptions. Nitroglycerin is used to prevent angina (chest pain) caused by coronary artery disease. This medicine is also used to relieve an angina attack that is already occurring. Nitroglycerin belongs to the group of medicines called nitrates. It works by relaxing the blood vessels and increasing the supply of blood and oxygen to the heart ...
Feb 17, 2020 · Recommended maximum: 2 doses/day; include a nitrate free-interval ~10 to 12 hours/day. Topical patch, transdermal: 0.2 to 0.4 mg/hour initially and titrate to doses of 0.4 to 0.8 mg/hour. Tolerance is minimized by using a patch-on period of 12 to 14 hours/day and patch-off period of 10 to 12 hours/day.
Nov 7, 2017 · Introduction. In this review, we detail the discovery of nitroglycerin and its early use in the treatment of angina; the history of the discovery of nitric oxide, its sources, and its roles; the mechanism of action, preparations, and hemodynamic and non-hemodynamic effects of the organic nitrates, as well as their biotransformation; and the clinical uses and adverse effects of nitrate therapy ...
