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The mesolimbic pathway is a collection of dopaminergic (i.e., dopamine -releasing) neurons that project from the ventral tegmental area (VTA) to the ventral striatum, which includes the nucleus accumbens (NAcc) and olfactory tubercle. [9] It is one of the component pathways of the medial forebrain bundle, which is a set of neural pathways that ...
Dopaminergic pathways. Dopaminergic pathways ( dopamine pathways, dopaminergic projections) in the human brain are involved in both physiological and behavioral processes including movement, cognition, executive functions, reward, motivation, and neuroendocrine control. [1] Each pathway is a set of projection neurons, consisting of individual ...
Mesolimbic pathway—transports dopamine from the VTA to the nucleus accumbens and amygdala. The nucleus accumbens is found in the ventral medial portion of the striatum and is believed to play a role in reward, desire, and the placebo effect. The amygdala is a key component of the limbic system and is associated with emotion.
The dopaminergic pathway mostly involved in reward is the so-called mesolimbic system, which is formed by projections of midbrain dopamine neurons of the ventral tegmental area (VTA) to the striatum, prefrontal cortex, amygdala, hippocampus, and many other structures of the limbic system.
- 10.1007/978-3-030-81147-1_4
- 2021
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The mesolimbic dopaminergic (ML-DA) system has been recognized for its central role in motivated behaviors, various types of reward, and, more recently, in cognitive processes. Functional theories have emphasized DA's involvement in the orchestration of goal-directed behaviors, and in the promotion and reinforcement of learning.
- Antonio Alcaro, Robert Huber, Jaak Panksepp, Jaak Panksepp
- 10.1016/j.brainresrev.2007.07.014
- 2007
- 2007/12
The mesolimbic pathway consists of dopamine neuron somata in the ventral tegmental area and projects to the ventral striatum, also known as the nucleus accumbens, for the control of reward processing. Functions of these pathways are affected in many brain disorders including Parkinson’s disease, schizophrenia and addiction.
Movement and motivation are regulated by two distinct dopaminergic pathways in the brain called the nigrostriatal and mesolimbic pathways. The nigrostriatal pathway transmits dopaminergic signals from the substantia nigra pars compacta (SNc) to the dorsal striatum (caudate-putamen [CPu]). This pathway controls movement, and defects in this ...
