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The mesolimbic pathway is a collection of dopaminergic (i.e., dopamine -releasing) neurons that project from the ventral tegmental area (VTA) to the ventral striatum, which includes the nucleus accumbens (NAcc) and olfactory tubercle. [9] It is one of the component pathways of the medial forebrain bundle, which is a set of neural pathways that ...
Dopaminergic pathways ( dopamine pathways, dopaminergic projections) in the human brain are involved in both physiological and behavioral processes including movement, cognition, executive functions, reward, motivation, and neuroendocrine control. [1] Each pathway is a set of projection neurons, consisting of individual dopaminergic neurons.
Mesolimbic pathway—transports dopamine from the VTA to the nucleus accumbens and amygdala. The nucleus accumbens is found in the ventral medial portion of the striatum and is believed to play a role in reward, desire, and the placebo effect. The amygdala is a key component of the limbic system and is associated with emotion.
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Jan 1, 2020 · The mesolimbic dopaminergic system is a key neural pathway that mediates reward, motivation, and cognition. This article reviews the current knowledge on the anatomy, physiology, and pharmacology of this system, as well as its involvement in various neuropsychiatric disorders, such as addiction, schizophrenia, and depression.
- Randal A. Serafini, Kerri D. Pryce, Venetia Zachariou
- 10.1016/j.biopsych.2019.10.018
- 2020
- 2020/01/01
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The mesolimbic dopaminergic (ML-DA) system has been recognized for its central role in motivated behaviors, various types of reward, and, more recently, in cognitive processes. Functional theories have emphasized DA's involvement in the orchestration of goal-directed behaviors, and in the promotion and reinforcement of learning.
Sep 28, 2018 · The mesolimbic hypothesis has been a central dogma of schizophrenia for decades, positing that aberrant functioning of midbrain dopamine projections to limbic regions causes psychotic symptoms. Recently, however, advances in neuroimaging techniques have led to the unanticipated finding that dopaminergic dysfunction in schizophrenia is greatest ...
