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  1. Mesolimbic pathway The mesolimbic pathway, sometimes referred to as the reward pathway, is a dopaminergic pathway in the brain. [1] The pathway connects the ventral tegmental area in the midbrain to the ventral striatum of the basal ganglia in the forebrain. The ventral striatum includes the nucleus accumbens and the olfactory tubercle. [2]

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  4. The mesolimbic pathway is thought to be involved in producing pleasurable feeling, and is often associated with feelings of rewardand desire, particularly because of the connection to the nucleus accumbens, which is also associated with these states. Because of this, this pathway is heavily implicated in neurobiologicaltheories of addiction.

  5. The mesolimbic pathway, sometimes referred to as the reward pathway, is a dopaminergic pathway in the brain. [1] The pathway connects the ventral tegmental area in the midbrain to the ventral striatum of the basal ganglia in the forebrain. The ventral striatum includes the nucleus accumbens and the olfactory tubercle. [2]

    • Anatomy
    • Controversy Over Mesolimbic Dopamine Function
    • Clinical Significance
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    The following structures are considered to be a part of the mesolimbic pathway: Ventral Tegmental Area 1. The ventral tegmental area (VTA) is a part of the midbrain. It consists of dopaminergic, GABAergic, and glutamatergic neurons.[2] The VTA communicates with the nucleus accumbens via the medial forebrain bundle. Nucleus Accumbens 1. The nucleus ...

    There is some controversy regarding dopamine’s role in the reward system. Three hypotheses — hedonia, learning, and incentive salience — have been proposed as explanations for dopamine’s function in the reward system.[1] The hedonia hypothesis suggests that dopamine in the nucleus accumbens acts as a 'pleasure neurotransmitter'. Historically, in th...

    Since the mesolimbic pathway is shown to be associated with feelings of reward and desire, this pathway is heavily implicated in neurobiological theories of addiction, schizophrenia, and depression.[6][7][8] Drug addiction, the loss of control over drug use or the compulsive seeking and taking of drugs despite adverse consequences, with the four ma...

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