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Monoamine oxidases (MAO) are flavoproteins that catalyze the deamination of monoamines, such as serotonin, norepinephrine, and dopamine. They are involved in the breakdown of monoamines in food and neurotransmitters, and are targets of some drugs used to treat psychiatric and neurological diseases.
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Like most antidepressants, MAOIs work by ultimately effecting changes in the brain chemistry that are operational in depression. An enzyme called monoamine oxidase is involved in removing the neurotransmitters norepinephrine, serotonin and dopamine from the brain.
- The Food and Drug Administration (FDA) has approved these MAOIs to treat depression: 1. Isocarboxazid (Marplan) 2. Phenelzine (Nardil) 3. Selegilin...
- Consider these issues and discuss them with your doctor before taking an MAOI: 1. Antidepressants and pregnancy. Some antidepressants may harm your...
- Most antidepressants are generally safe, but the FDA requires that all antidepressants carry black box warnings, the strictest warnings for prescri...
- Talk to your doctor before you stop taking an MAOI. Stopping treatment with MAOIs has been associated with flu-like symptoms, including anxiety, ag...
- Each person reacts differently to a particular antidepressant and may be more likely to have certain side effects. Because of this, one antidepress...
Monoamine oxidase is an enzyme that breaks down neurotransmitters like serotonin, dopamine, and norepinephrine. It has two isoforms (A and B) with different substrate specificity, tissue distribution, and inhibitor selectivity. Learn more about its structure, function, and role in various disorders and diseases.
Monoamine oxidase enzymes are responsible for the degredation of serotonin, dopamine, and norepinephrine in the central neurvous system. Although it has been nearly 100 years since they were first described, we are still learning about their role in the healthy brain and how they are altered in vari ….
- Danielle N. Jones, Mary Ann Raghanti
- 2021
Monoamine oxidase (MAO) (monoamine; oxygen oxidoreductase, deaminating, EC 1.4.3.4) catalyzes the oxidative deamination of a number of biogenic amines in the brain and peripheral tissues by the production of hydrogen peroxide (H 2 O 2) (Shih 1991, Thorpe et al 1987).
- J. C. Shih, K. Chen, M. J. Ridd
- 10.1146/annurev.neuro.22.1.197
- 1999
- 1999
Oct 1, 2011 · The monoamine oxidase family of flavoenzymes catalyze the oxidation of primary and secondary amines, polyamines and amino acids. Despite low levels of sequence identity, structures of the MAO family are homologous, with a conserved FAD-binding site and a novel lysine-water-flavin interaction.
Monoamine oxidase (MAO) A and B isoenzymes located at the mitochondrial outer membrane, catalyze the oxidative deamination of monoamine neurotransmitters in both the brain and peripheral tissues, and produce hydrogen peroxide (H 2 O 2) as one of the products.
