The rash consists of macular lesions that are red and usually 2–10 mm in diameter but may be confluent in places. A morbilliform rash is a rose-red flat ( macular ) or slightly elevated ( maculopapular ) eruption, showing circular or elliptical lesions varying in diameter from 1 to 3 mm, with healthy-looking skin intervening.
The diagnosis may confirm any number of conditions. The presence of a rash may aid diagnosis; associated signs and symptoms are diagnostic of certain diseases. For example, the rash in measles is an erythematous, morbilliform, maculopapular rash that begins a few days after the fever starts. It classically starts at the head, and spreads downwards.
The rash can also occur in adults. The rash is described as maculopapular or morbilliform (measles-like; therefore, in medical literature, it is called "amoxicillin-induced morbilliform rash".). It starts on the trunk and can spread from there.
- Hundreds of names
- AU: A, US: B (No risk in non-human studies)
- less than 30% biotransformed in liver
The most common type of eruption is a morbilliform (resembling measles) or erythematous rash (approximately 90% of cases). Less commonly, the appearance may also be urticarial, papulosquamous, pustular, purpuric, bullous (with blisters) or lichenoid. Angioedema can also be drug-induced (most notably, by angiotensin converting enzyme inhibitors).
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morbilliform rash: An exanthema commonly due to echovirus 9, consisting of fine, discrete maculopapules on the head and neck, rarely elsewhere; the rash and characteristic low-grade fever usually resolve in a week. DiffDx Rubella, meningococcal petechiae-Waterhouse-Friderichsen syndrome, Kawasaki’s disease.
Morbilliform drug eruption is a form of allergic reaction. It is mediated by cytotoxic T-cells and classified as a Type IV immune reaction. The target of attack may be drug, a metabolite of the drug, or a protein bonded to the drug.
The onset of a morbilliform eruption (MDE; also known as exanthematous or maculopapular drug eruption) typically occurs within 7 to 10 days after the initiation of the culprit drug. Occasionally a 14-day window has been noted. On rechallenge with a drug that the patient has been sensitized to in the past, the eruption may occur within 24 hours.
The rash appears as rounded about 2 to 10 mm in diameter macular lesions. The rash is confluent in places. Morbilliform rash is a symptom of many diseases like Kawasaki disease, meningococcal petechiae, water house Friderichsen syndrome, dengue, rubella, and syphilis and echo virus. Morbilliform rash is a type of maculopapular rash.
Symptoms generally include fever, an often itchy rash which may be morbilliform or consist mainly of macules or plaques, facial edema (i.e. swelling, which is a hallmark of the disease), enlarged and sometimes painful lymph nodes, and other symptoms due to inflammation-based internal organ involvement, most commonly liver, less commonly kidney ...
Morbilliform Drug Eruption. Prev Next Drug hypersensitivity reaction. Eczematous, targetoid rash on the trunk occuring 1 week after the administration of a systemic cephalosporin. Color Atlas ...