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The rash consists of macular lesions that are red and usually 2–10 mm in diameter but may be confluent in places. A morbilliform rash is a rose-red flat or slightly elevated (maculopapular) eruption, showing circular or elliptical lesions varying in diameter from 1 to 3 mm, with healthy-looking skin intervening. [citation needed]
Mar 4, 2022 · Morbilliform eruptions inspire a broad and varied differential spanning across inflammatory and infectious categories. The goal of this article is to help the clinician develop an approach toward the pediatric patient with a morbilliform eruption in the emergency room or hospital setting.
- 10.1016/j.det.2021.12.006
- 2022/04
- Dermatol Clin. 2022 Apr; 40(2): 191-202.
- What Is Morbilliform Drug reaction?
- Who Gets Morbilliform Drug Eruption?
- What Causes Morbilliform Drug Eruption?
- What Are The Clinical Features of Morbilliform Drug Eruption?
- What Are The Complications of Morbilliform Drug Eruption?
- How Is Morbilliform Drug Eruption Diagnosed?
- What Is The Treatment For Morbilliform Drug Eruption?
- How Can Morbilliform Drug Eruption Be Prevented?
- What Is The Outlook For Morbilliform Drug Eruption?
Morbilliform drug eruption is the most common form of drug eruption. Many drugs can trigger this allergic reaction, but antibiotics are the most common group. The eruption may resemble exanthems caused by viral and bacterial infections. 1. A morbilliform skin rashin an adult is usually due to a drug. 2. In a child, it is more likely to be viral in ...
About 2% of prescriptions of new drugs cause a drug eruption. About 95% of these are morbilliform drug eruptions. They mainly affect people prescribed beta-lactam antibiotics (penicillins, cephalosporins), sulfonamides, allopurinol, anti-epileptic drugs and nonsteroidal anti-inflammatory drugs (NSAID). Numerous other drugs have been reported to cau...
Morbilliform drug eruption is a form of allergic reaction. It is mediated by cytotoxic T-cells and classified as a Type IV immune reaction. The target of attack may be drug, a metabolite of the drug, or a protein bonded to the drug. Inflammation follows the release of cytokines and other effector immune cells.
On the first occasion, a morbilliform rash usually appears 1–2 weeks after starting the drug, but it may occur up to 1 week after stopping it. On re-exposure to the causative (or related) drug, skin lesionsappear within 1–3 days. It is very rare for a drug that has been taken for months or years to cause a morbilliform drug eruption. Morbilliform d...
In the early phase, it may not be possible to clinically distinguish an uncomplicated morbilliform eruption from other more serious cutaneous adverse reactions(SCAR). These are: 1. Drug hypersensitivity syndrome 2. Stevens Johnson syndrome – toxic epidermal necrolysis(SJS/TEN) 3. Acute generalised exanthematous pustulosis(AGEP) Patients with the fo...
A strong clinical suspicion of morbilliform drug eruption depends on: 1. Typical exanthematous rash 2. Recently introduced medication To identify the possible causative drug, a drug calendar, including all prescribed and over-the counter products, may be helpful. The starting date of each new drug is documented together with the onset of the rash. ...
The most important thing is to identify the causative drug and if possible, stop it. If the reaction is mild, and the drug is essential and not replaceable, obtain a specialist opinion whether it is safe to continue the drug before doing so. 1. Monitor the patient carefully in case of complications. 2. Apply emollients and potent topical steroid cr...
It is not possible to completely prevent morbilliform eruptions. Prescribers must be vigilant. Their incidencemay be reduced by: 1. Minimising prescriptions for antibiotics 2. Educating the patient about the cause of their rash and the danger of re-exposure to the same medication 3. Adding the reaction to the medical record alerts
If the causative drug is ceased, the rash begins to improve within 48 hours and clears within 1–2 weeks. If the drug is continued, the rash may: 1. Resolve despite continued exposure to the drug 2. Persistwithout change 3. Progress to erythroderma
Sep 23, 2020 · With 1 week of trimethoprim–sulfamethoxazole, she developed a diffuse maculopapular, erythematous rash. On physical examination, her body temperature was 38.4℃. Diffuse erythema was noted over the face, neck, trunk, arms, and legs ( figure 1 ). She had no mucosal involvement.
- Daisuke Takenaka, Toshinori Nishizawa
- 10.1136/bcr-2020-238255
- 2020
- BMJ Case Rep. 2020; 13(9): e238255.
Morbilliform eruptions inspire a broad and varied differential spanning across inflammatory and infectious categories. The goal of this article is to help the clinician develop an approach toward the pediatric patient with a morbilliform eruption in the emergency room or hospital setting.
The rash of measles is described as morbilliform, and this adjective is used to describe similar-appearing eruptions of macules and papules. Frequently, these rashes present in conjunction with fever, and additional nonspecific symptoms include myalgia, rhinorrhea, conjunctivitis, headache, gastrointestinal (GI) symptoms, and lymphadenopathy.
Sep 9, 2004 · History of symptoms—Ask about the duration and height of the fever and the sequence of fever and rash development. A rash that appears as the fever resolves is typical of roseola infantum. In erythema infectiosum “slapped cheeks” and a lace-like rash may occur up to a week after fever.
