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1.1 ABCs of Drug Rashes; 1.2 Rash Red Flags [1] 2 Clinical Features; 3 Differential Diagnosis. 3.1 Erythematous rash; 3.2 Plaques; 4 Evaluation. 4.1 Table of Severe Drug Rashes; 5 Management; 6 Disposition; 7 See Also; 8 External Links; 9 References
Dec 22, 2022 · The morbilliform rash is a flat, red rash that appears on the skin and resembles measles, while urticaria is a raised, itchy rash that can appear as welts or hives. An allergic reaction typically causes urticaria, whereas morbilliform rash can have various causes, including medication reactions, viral infections, or bacterial infections.
Jul 18, 2023 · The morbilliform eruption is the most commonly observed cutaneous irAE. It affects approximately 49–68% of patients undergoing anti-CTLA-4 therapy and 20% of patients receiving PD-1/PD-L1 inhibitors [13, 47]. Typically, the morbilliform rash occurs within the first three to six weeks after initiating ICIs treatment [10, 12, 48, 49]. Clinical ...
Mar 13, 2019 · The onset of a morbilliform eruption (MDE; also known as exanthematous or maculopapular drug eruption) typically occurs within 7 to 10 days after the initiation of the culprit drug. Occasionally a 14-day window has been noted. On rechallenge with a drug that the patient has been sensitized to in the past, the eruption may occur within 24 hours.
This non-itchy rash begins on the face and behind the ears. Within 24–36 hours it spreads over the entire trunk and extremities (palms and soles rarely involved). The spots may join together, especially in areas of the face. The onset of the rash usually coincides with a high fever of at least 40C.
Mar 8, 2021 · exanthematous drug eruption drug rash. Diagnosis # Exanthematous drug eruption, also known as a morbilliform or maculopapular drug eruption, is the most common type of drug hypersensitivity reaction [1]. Diagnosis of exanthematous drug eruption should be suspected in a patient receiving drug treatment who presents with a new onset rash.
Pathogenesis. The pathogenesis of a morbilliform drug eruption is not understood, and very little research has been directed toward resolving the mechanism(s) involved. The frequent development of morbilliform drug eruptions precipitated by ampicillin in a patient with Epstein-Barr virus infection and by sulfonamides in a patient with HIV infection suggests that an altered immune system may be ...
