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  1. Apr 19, 2023 · 1. Ischemic heart disease, or coronary artery disease. The deadliest disease in the world is coronary artery disease (CAD). Also called ischemic heart disease, CAD occurs when the...

    • Ann Pietrangelo
  2. Tuberculosis (TB) is the deadliest infectious disease. More than 600,000 people developed drug-resistant TB in 2016. Influenza infects up to 5 million people per year. Around 94% of malaria fatalities are in sub-Saharan Africa.

    • The Black Death: Bubonic Plague. The Black Death ravaged most of Europe and the Mediterranean from 1346 until 1353. Over 50 million people died, more than 60% of Europe's entire population at the time.
    • The Speckled Monster: Smallpox. The origins of smallpox have been lost in prehistory but research suggests it first appeared around 10,000 BC. Telltale pockmarks adorn the mummified remains of the great Egyptian Pharaoh Ramses V (dated 1156 BC) and the disease is described in ancient Sanskrit texts.
    • Severe Acute Respiratory Syndrome (SARS) The history of SARS was short but not so sweet. SARS generated widespread panic in 2003 and was caused by a previously unknown coronavirus (SARS-CoV-1) - the same family of viruses that causes Covid-19.
    • Avian Influenza: Not Just One For The Birds. Just like humans, birds get the flu. Bird flu - also called Avian influenza - is common and several major outbreaks have occurred sporadically worldwide since the disease was first recorded in Italy in 1878.
  3. Apr 2, 2020 · Deadliest infectious diseases in the world, ranked. By Jessica Learish. Updated on: April 2, 2020 / 2:51 PM EDT / CBS News. Anthony Kwan/Getty Images. COVID-19 has spread to nearly every corner...

  4. Pandemics timeline death tolls. This is a list of the largest known epidemics and pandemics caused by an infectious disease in humans. Widespread non-communicable diseases such as cardiovascular disease and cancer are not included.

    Event
    Years
    Location
    Disease
    1350 BC plague of Megiddo
    c. 1350 BC
    Megiddo, land of Canaan
    Amarna letters EA 244, Biridiya, mayor of ...
    Hittite Plague /"Hand of Nergal"
    c. 1330 BC
    Near East, Hittite Empire, Alashiya, ...
    Unknown, possibly Tularemia. Mentioned in ...
    430–426 BC
    Greece, Libya, Egypt, Ethiopia
    Unknown, possibly typhus, typhoid fever ...
    412 BC
    Greece ( Northern Greece, Roman Republic ...
    Unknown, possibly influenza
  5. Jan 29, 2023 · Its toll: Although the fatality level is less than 1% and the disease is mild for most people, about 8% to 10% of people infected develop severe symptoms, including eye lesions, encephalitis...

  6. Mar 18, 2024 · Heart disease, cancer, and unintentional injury are the three most common causes of death in the United States. In recent years COVID-19 has significantly impacted mortality, but this is now...

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