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Dec 30, 2020 · Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine. ... These side effects were transient, starting about 15 hours after vaccination and resolving in most participants by day 2, without ...
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Mar 17, 2023 · 3.4.1. mRNA‐1273 (Moderna) A smaller number of studies (n = 18) in the review reported 444 CV events in individuals who received the mRNA‐1273 (Moderna) vaccine at first, second, or both doses; 4 studies included both types of mRNA vaccines were previously published. Figure 2 presents the CV complications in mRNA‐1273 (Moderna) cohort ...
- 10.1002/iid3.807
- 2023/03
- Immun Inflamm Dis. 2023 Mar; 11(3): e807.
- Overview
- mRNA vaccine characteristics
- Common side effects
- Rare side effects: Myocarditis, pericarditis
- Allergies and anaphylaxis
- Dermal fillers
The Moderna COVID-19 vaccine is a two-dose vaccine to prevent COVID-19. This Snapshot feature looks at the possible side effects and safety recommendations associated with this mRNA vaccine.
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Moderna’s COVID-19 vaccine, also known as mRNA-1273, is a two-dose vaccine. The doses are administered 28 days apart, and the vaccine trains the immune system to fight against future infections with SARS-CoV-2, the virus that causes COVID-19.
Moderna’s vaccine has authorization for use in a total of 53 countries. The Food and Drug Administration (FDA) has issued this authorization for people in the United States aged 18 or older. The vaccine has also been authorized for use across the European Union after a recommendation by the European Medicines Agency, as well as in Canada and the United Kingdom.
Like the Pfizer-BioNTech vaccine, the Moderna vaccine is an mRNA vaccine. While these two are the first mRNA vaccines to be authorized for use in humans, scientists have been researching this technology for many years.
An mRNA vaccine functions by providing the body with genetic information to produce viral or bacterial proteins, in this case, the spike protein found on the surface of SARS-CoV-2. These proteins trigger an immune response and the production of specific antibodies, preparing the body to fight off an infection if it comes into contact with the pathogen in the future.
The vaccine only carries the information needed to make a small part of the virus. It does not contain the SARS-CoV-2 virus, and it cannot cause COVID-19.
Enzymes in our cells quickly degrade the mRNA molecules in the vaccine once the spike protein has been made. It is not possible for the vaccine to alter the body’s genetic information.
The FDA’s fact sheet for this vaccine lists the following general side effects. Also, we have included the percentages of frequency reported in Moderna’s phase 3 clinical trial data:
•fatigue (70%)
•headache (64.7%)
•muscle pain (61.5%)
•joint pain (46.4%)
•chills (45.4%)
Following some reports of myocarditis, or inflammation of the heart muscle, and pericarditis, which is inflammation of the lining outside the heart, after the receipt of mRNA vaccines, the FDA added revisions to both the patient and healthcare provider fact sheets for the Moderna vaccine.
In the patient fact sheet for the Moderna vaccine, the FDA notes that symptoms of myocarditis or pericarditis tend to appear “within a few days following receipt of the second dose.” However, the FDA, adds, these side effects are very unlikely to occur in most people.
The federal agency also advises that those who do experience myocarditis or pericarditis symptoms after vaccination should seek medical attention immediately. The symptoms include chest pain, shortness of breath, and “feelings of having a fast-beating, fluttering, or pounding heart.”
According to the CDC, these side effects within the heart are most likely to occur in adolescents and young adults. Most of those who receive immediate care respond well to treatment, and their condition quickly improves, the agency adds.
Allergic reactions, severe and otherwise, have been reported as possible side effects of the vaccine, as a response to certain ingredients in the vaccine.
Anaphylaxis, a severe allergic reaction, is a rare side effect of vaccination. Out of 7,581,429 Moderna vaccine doses administered, there have been 19 reports of anaphylaxis, fewer than 3 cases per million.
The vaccine fact sheet lists the following potential symptoms of a severe allergic reaction:
•difficulty breathing
•swelling of the face and throat
•a rapid heartbeat
Moderna reported three cases of lip or facial swelling in clinical trial participants who had previously had a dermal filler cosmetic injection. The company said that the reactions were likely related to vaccination.
A possible explanation for this side effect is that the spike protein of the SARS-CoV-2 virus, which the mRNA helps the body to produce, interacts with regions around the dermal filler and induces an inflammatory response.
The CDC report that “Infrequently, people who have received dermal fillers might experience swelling at or near the site of filler injection (usually face or lips) following administration of a dose of an mRNA COVID-19 vaccine.”
The agency says that people who have dermal fillers can have mRNA COVID-19 vaccines but that they should contact a healthcare professional if they experience any swelling after the vaccination.
Jul 22, 2023 · Serious side effects. Along with its needed effects, sars-cov-2 (covid-19) mrna-1273 vaccine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor or nurse immediately if any of the following side effects occur while taking sars-cov-2 (covid-19 ...
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Dec 30, 2020 · About 50% of participants receiving mRNA-1273 experienced moderate-to-severe side effects — such as fatigue, muscle aches, joint pain and headache — after the second dose, which resolved in most volunteers within two days. Investigators also observed no evidence of VAERD among those who received mRNA-1273.
May 5, 2021 · There are concerns regarding the side effects of the new coronavirus disease 2019 (COVID‐19) mRNA‐1273 vaccine among healthcare workers (HCWs) in the United States. The objective of the study was to investigate the side effects of the mRNA‐1273 vaccine with detailed review of organ systems.
Sep 22, 2021 · The phase 3 trial of mRNA-1273, a lipid nanoparticle–encapsulated mRNA expressing the prefusion-stabilized spike glycoprotein of SARS-CoV-2, 11 showed a 94.1% vaccine efficacy against Covid-19 ...
