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  1. A literature study was performed of deaths due to alcohol-induced seizures, either during withdrawal or as late-onset seizures where the aetiology was established as long time alcohol abuse and a...

    • Abstract
    • Materials and Methods
    • Results
    • Discussion

    A specific analysis of fatality and its causes in alcoholic withdrawal syndrome (AWS) has rarely been made. On many occasions, different studies make no reference to causes of death (Ferguson et al., 1996; Foy et al., 1997; Lukan et al., 2002) and there are few available data from autopsies (Tavel et al., 1961; Salum, 1972). It is not easy to evalu...

    Study design

    We have presented a retrospective cohort study on the clinical outcome and mortality rate of patients diagnosed with AWS. In a consecutive series of patients admitted to a general hospital with AWS, characteristics of cases with a fatal outcome are compared with those of survivors.

    Study population

    The study was carried out at the Xeral-Calde Hospital in Lugo (Spain) between January 1987 and December 2003. This center is a provincial university hospital with a 735-bed capacity, covering an area with a population of 221,441 inhabitants under the Spanish National Health Care System. All patients diagnosed with AWS and admitted either to medical or surgical services during this period were studied. Patients are not electively admitted for detoxification in our hospital. However, people who...

    Data collection

    Our hospital’s ethics committee approved the study. Cases were identified by code searching in the computerized database of the hospital. For each of the cases identified as AWS or DT in the database, the diagnoses of alcohol withdrawal syndrome and alcohol withdrawal delirium (DT) were reviewed by the investigators in accordance with the criteria established by the Diagnostic and Statistical Manual of Mental Disorders, 4th ed (DSM-IV)-TR manual (American Psychiatric Association, 2000). Data...

    We studied 539 episodes of hospitalization for AWS in 436 patients. The mean age was 45.0 (SD 12.0), with a range between 20 and 75; 492 were men (91.3%). Alcohol withdrawal was the cause of admission in 336 cases (62.3%), while 203 (37.6%) were admitted for other causes and subsequently developed AWS during their hospital stay. One hundred forty-n...

    The main findings of this study are that the factors which determine survival after hospital admission for AWS depend both on the intensity of the clinical manifestations (DT, ICU) and the presence of associated comorbidity. The death rate in our series (6.6%) is within the range of that observed in similar studies, where death rates of between 5 a...

    • R. Monte, R. Rabuñal, E. Casariego, H. López-Agreda, A. Mateos, S. Pértega
    • 2010
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  3. Alcoholic neuropathy was documented at least as early as 1787 by English physician and philanthropist John Coakley Lettsom (1744-1815) ( 133 ), but other neurologic complications of alcoholism were probably not recognized until the end of the 19th century or later. Alcohol-related deficits in memory and intellectual ability were reported in ...

  4. Next, the Division reviewed recent publications on the magnitude of alcohol-related mortality in the U.S. Midanik et al. (2004) reported that there were over 75,000 alcohol attributable deaths in the United States in 2001, and identified excessive alcohol consumption as the third leading preventable cause of death in the U.S. Approximately ...

  5. Aug 31, 2016 · Moderate drinking can reduce the incidence and mortality of coronary artery disease, heart failure, diabetes, ischemic and hemorrhagic stroke. More than this amount can lead to alcoholic cardiomyopathy, which is defined as alcohol toxicity to the heart muscle itself by ethanol and its metabolites.

    • B Maisch
    • 2016
  6. Jun 22, 2007 · After a properly conducted autopsy, a small proportion of cases will not reveal a cause of death. This is probably of the order of 2–5%. However, before the death is recorded as unascertained, it is important that appropriate ancillary investigations have been conducted. These tests include toxicology, microbiology and genetic testing where appropriate. The history and scene examination ...