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  1. Mar 03, 2021 · Neonatal sepsis refers to an infection involving the bloodstream in newborn infants less than 28 days old. It remains a leading cause of morbidity and mortality among neonates, especially in middle and lower-income countries [1]. Neonatal sepsis is divided into two groups based on the time of presentation after birth: early-onset sepsis (EOS) and late-onset sepsis (LOS). EOS refers to sepsis ...

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    Neonatal sepsis can be caused by bacteria such as Escherichia coli (E coli), Listeria, and some strains of streptococcus. Group B streptococcus (GBS) has been a major cause of neonatal sepsis. However, this problem has become less common because women are screened during pregnancy. The herpes simplex virus (HSV) can also cause a severe infection in a newborn baby. This happens most often when the mother is newly infected.

    Early-onset neonatal sepsis most often appears within 24 to 48 hours of birth. The baby gets the infection from the mother before or during delivery. The following increase an infant's risk of early-onset bacterial sepsis:

    Babies with late-onset neonatal sepsis are infected after delivery. The following increase an infant's risk of sepsis after delivery:

  2. Mar 03, 2021 · Neonatal sepsis is divided into two groups based on the time of presentation after birth: early-onset sepsis (EOS) and late-onset sepsis (LOS). EOS refers to sepsis in neonates at or before 72 hours of life ( some experts use seven days), and LOS is defined as sepsis occurring at or after 72 hours of life .

  3. Jun 19, 2019 · Neonatal sepsis can also be defined as clinically diagnosed or confirmed by positive culture in a typically sterile bodily fluid. The gold standard for the diagnosis of neonatal sepsis is a positive culture in the blood, urine, cerebrospinal fluid, peritoneal fluid, or any other sterile tissues [13, 14].

  4. Purpose of review: Neonatal sepsis is a diagnosis made in infants less than 28 days of life and consists of a clinical syndrome that may include systemic signs of infection, circulatory shock, and multisystem organ failure.

  5. Prognosis for Neonatal Sepsis. The fatality rate is 2 to 4 times higher in LBW infants than in full-term infants. The overall mortality rate of early-onset sepsis is 3 to 40% (that of early-onset GBS infection is 2 to 10%) and of late-onset sepsis is 2 to 20% (that of late-onset GBS is about 2%).

  6. Sepsis is a serious medical condition caused by the body's response to an infection. In newborns, sepsis can cause swelling throughout the body and possible organ failure.

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