- related to: neonatal sepsis definition
The term sepsis describes a very serious type of infection that usually enters the body. Sometimes sepsis happens through visible outer wounds, although sometimes sepsis
Neonatal sepsis definition
- Definition of neonatal sepsis The term neonatal sepsis is used to designate a systemic condition of bacterial, viral, or fungal (yeast) origin that is associated with haemodynamic changes and other clinical manifestations and results in substantial morbidity and mortality. Despite years of clinical
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Neonatal sepsis is a common, devastating, and expensive disease with life-long impact plagued by a lack of accurate diagnostic and prognostic testing. Management options and outcomes have not changed for the last 30 years. There is remarkable heterogeneity among studies regarding the case definition of neonatal sepsis.
- James L. Wynn
Oct 10, 2021 · Neonatal sepsis refers to an infection involving the bloodstream in newborn infants less than 28 days old. It remains a leading cause of morbidity and mortality among neonates, especially in middle and lower-income countries . Neonatal sepsis is divided into two groups based on the time of presentation after birth: early-onset sepsis (EOS) and late-onset sepsis (LOS). EOS refers to sepsis ...
Neonatal sepsis can be caused by bacteria such as Escherichia coli (E coli), Listeria, and some strains of streptococcus. Group B streptococcus (GBS) has been a major cause of neonatal sepsis. However, this problem has become less common because women are screened during pregnancy. The herpes simplex virus (HSV) can also cause a severe infection in a newborn baby. This happens most often when the mother is newly infected.
Early-onset neonatal sepsis most often appears within 24 to 48 hours of birth. The baby gets the infection from the mother before or during delivery. The following increase an infant's risk of early-onset bacterial sepsis:
Babies with late-onset neonatal sepsis are infected after delivery. The following increase an infant's risk of sepsis after delivery:
The lack of an accepted consensus definition for neonatal sepsis impedes our efforts toward improved diagnostic and prognostic options, and accurate outcomes information for this vulnerable population.
- James L. Wynn
Introduction: Neonatal sepsis is a leading cause of infant mortality worldwide with non-specific and varied presentation. We aimed to catalogue the current definitions of neonatal sepsis in published randomised controlled trials (RCTs).
- Rían Hayes, Jack Hartnett, Gergana Semova, Cian Murray, Katherine Murphy, Leah Carroll, Helena Plapp...