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1. publications.aap.org › pediatrics › articleClinical Practice Guideline: Evaluation and Management of ...

   publications.aap.org › pediatrics › article

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   Aug 1, 2021 · This guideline addresses the evaluation and management of well-appearing, term infants, 8 to 60 days of age, with fever ≥38.0°C. Exclusions are noted. After a commissioned evidence-based review by the Agency for Healthcare Research and Quality, an additional extensive and ongoing review of the literature, and supplemental data from published, peer-reviewed studies provided by active ...

2. publications.aap.org › pediatricsinreview › articleEarly-Onset Sepsis in Newborns | Pediatrics In Review ...

   publications.aap.org › pediatricsinreview › article

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   Jan 1, 2023 · Abstract. Early-onset sepsis can cause significant morbidity and mortality in newborn infants. Risk factors for sepsis include birth to mothers with inadequately treated maternal group B Streptococcus colonization, intra-amniotic infection, maternal temperature greater than 100.4°F (>38°C), rupture of membranes greater than 18 hours, and ...

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   How is early onset neonatal sepsis treated?

   • The only intervention proven to decrease the incidence of early-onset neonatal sepsis is maternal treatment with intrapartum intravenous antimicrobial agents for the prevention of GBS infections. 93 Adequate prophylaxis is defined as penicillin (the preferred agent), ampicillin, or cefazolin given for ≥4 hours before delivery.

   Management of Neonates With Suspected or Proven Early-Onset Bacter…

   publications.aap.org/pediatrics/article/129/5/1006/73781/Management-of-Neonates-With-Suspected-or-Proven

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   How is sepsis diagnosed in the neonate?

   • The clinical diagnosis of sepsis in the neonate is difficult, because many of the signs of sepsis are nonspecific and are observed with other noninfectious conditions. Although a normal physical examination is evidence that sepsis is not present, bacteremia can occur in the absence of clinical signs.

   Clinical Guideline for Management of Neonates with Suspected or ... - …

   platform.who.int/docs/default-source/mca-documents/policy-documents/operational-guidance/ARE-MN-62-09-OPERATIONALGUIDANCE-2017-eng-Clinical-Guideline-for-Management-of-Neonates-with-Bacterial-Sepsis.pdf

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   What is a clinicopathologic approach to neonatal sepsis?

   • Clinicopathologic approach to the diagnosis of neonatal sepsis. Volume of blood required to detect common neonatal pathogens. Neonatal Escherichia coli septicemia—bacterial counts in blood. Frequency of low level bacteremia in infants from birth to two months of age. Volume of blood submitted for culture from neonates.

   Management of Neonates With Suspected or Proven Early-Onset Bacter…

   publications.aap.org/pediatrics/article/129/5/1006/73781/Management-of-Neonates-With-Suspected-or-Proven

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4. platform.who.int › docs › default-sourceClinical Guideline for Management of Neonates with ... - WHO

   platform.who.int › docs › default-source

   Clinical Guideline for Management of Neonates with Suspected or Proven Early-Onset Bacterial Sepsis _____ 1. Background Early-onset bacterial sepsis (EOS) defined by the National Institute of Child Health and Human Development and Vermont Oxford Networks as sepsis with onset at ≤72 hr of age.