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  1. Neonatal sepsis - Wikipedia › wiki › Sepsis_of_newborn

    Neonatal sepsis is the single most common cause of neonatal death in hospital as well as community in developing country. It is difficult to clinically exclude sepsis in newborns less than 90 days old that have fever (defined as a temperature > 38 °C (100.4 °F).

  2. Neonatal infection - Wikipedia › wiki › Sepsis_neonatorum

    Neonatal sepsis of the newborn is an infection that has spread through the entire body. The inflammatory response to this systematic infection can be as serious as the infection itself. [3] In infants that weigh under 1500 g, sepsis is the most common cause of death.

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  4. Neonatal sepsis — Wikipedia Republished // WIKI 2 › en › Neonatal_sepsis
    • Signs and Symptoms
    • Risk Factors
    • Diagnosis
    • Treatment
    • Epidemiology
    • Research

    The signs of sep­sis are non-spe­cific and include: 1. Body temperature changes 2. Breathing problems 3. Diarrhea 4. Low blood sugar (hypoglycemia) 5. Reduced movements 6. Reduced sucking 7. Seizures 8. Bradycardia 9. Swollen belly area 10. Vomiting 11. Yellow skin and whites of the eyes (jaundice). 12. hemorrhagic rash A heart rate above 160 can also be an in­di­ca­tor of sep­sis, this tachy­car­dia can pre­sent up to 24 hours be­fore the onset of other signs.

    A study per­formed at Strong Memo­r­ial Hos­pi­tal in Rochester, New York, showed that in­fants ≤ 60 days old meet­ing the fol­low­ing cri­te­ria were at low-risk for hav­ing a se­ri­ous bac­te­r­ial illness: 1. generally well-appearing 2. previously healthy 2.1. full term (at ≥37 weeks gestation) 2.2. no antibiotics perinatally 2.3. no unexplained hyperbilirubinemia that required treatment 2.4. no antibiotics since discharge 2.5. no hospitalizations 2.6. no chronic illness 2.7. discharged at the same time or before the mother 3. no evidence of skin, soft tissue, bone, joint, or ear infection 4. White blood cells (WBCs) count 5,000-15,000/mm3 5. absolute band count ≤ 1,500/mm3 6. urine WBC count ≤ 10 per high power field (hpf) 7. stool WBC count ≤ 5 per high power field (hpf) only in infants with diarrhea Those meet­ing these cri­te­ria likely do not re­quire a lum­bar punc­ture, and are felt to be safe for dis­charge home with­out an­tibi­otic treat­ment, or with a sin­gle dose of...

    Neona­tal sep­sis screening:[citation needed] 1. DLC (differential leukocyte count) showing increased numbers of polymorphs. 2. DLC: band cells > 20%. 3. increased haptoglobins. 4. micro ESR (erythrocyte sedimentation rate) titer > 15mm. 5. gastric aspirate showing > 5 polymorphs per high power field. 6. newborn CSF (cerebrospinal fluid) screen: showing increased cells and proteins. 7. suggestive history of chorioamnionitis, PROM (premature rupture of membranes), etc... Cul­tur­ing for mi­croor­gan­isms from a sam­ple of CSF, blood or urine, is the gold stan­dard test for de­fin­i­tive di­ag­no­sis of neona­tal sep­sis. This can give false neg­a­tives due to the low sen­si­tiv­ity of cul­ture meth­ods and be­cause of con­comi­tant an­tibi­otic ther­apy. Lum­bar punc­tures should be done when pos­si­ble as 10-15% pre­sent­ing with sep­sis also have menin­gi­tis, which war­rants an an­tibi­otic with a high CSF penetration.[citation needed] CRP is not very ac­cu­rate in pick­ing up cases.

    Note that, in neonates, sep­sis is dif­fi­cult to di­ag­nose clin­i­cally. They may be rel­a­tively asymp­to­matic until he­mo­dy­namic and res­pi­ra­tory col­lapse is im­mi­nent, so, if there is even a re­mote sus­pi­cion of sep­sis, they are fre­quently treated with an­tibi­otics em­pir­i­cally until cul­tures are suf­fi­ciently proven to be neg­a­tive. In ad­di­tion to fluid re­sus­ci­ta­tion and sup­port­ive care, a com­mon an­tibi­otic reg­i­men in in­fants with sus­pected sep­sis is a beta-lac­tam an­tibi­otic (usu­ally ampi­cillin) in com­bi­na­tion with an amino­gly­co­side (usu­ally gen­tam­icin) or a third-gen­er­a­tion cephalosporin (usu­ally ce­fo­taxime—cef­tri­ax­one is gen­er­ally avoided in neonates due to the the­o­ret­i­cal risk of ker­nicterus.) The or­gan­isms which are tar­geted are species that pre­dom­i­nate in the fe­male gen­i­touri­nary tract and to which neonates are es­pe­cially vul­ner­a­ble to, specif­i­cally Group B Strep­to­coc­cus, Es­cherichia coli,...

    Since the 1990s early-on­set sep­sis has de­clined be­cause of screen­ing of group B strep­to­coc­cus. The cause of early-on­set neona­tal sep­sis are pathogens that con­t­a­m­i­nate the pla­centa, vagi­nal canal, cervix, or am­ni­otic fluid, and these pathogens can af­fect the baby ei­ther in the womb or dur­ing labor. Early-on­set neona­tal sep­sis is found to be 0.77 to 1 per 100,000 live births in the U.S. In pre­ma­ture ba­bies, the in­ci­dence and mor­tal­ity rates are higher due to the weak­ness of their im­mune sys­tem. For in­fants with low birth weight, cases of early-on­set sep­sis is found to be about 26 per 1,000 and 8 per 1,000 live births. Cer­tain pop­u­la­tions of ba­bies are at more risk as well. Moth­ers who have poor health­care, low so­cioe­co­nomic sta­tus, sub­stance abuse, or are African Amer­i­can have higher rates of neona­tal sep­sis. In fact, African Amer­i­can preterm ba­bies have the high­est rate of in­fec­tion and mor­tal­ity. 5.14 of every 1,000 live...

    Tri­als of pro­bi­otics for pre­ven­tion of neona­tal sep­sis have gen­er­ally been too small and sta­tis­ti­cally un­der­pow­ered to de­tect any benefit, but a ran­dom­ized con­trolled trial that en­rolled 4,556 neonates in India re­ported that pro­bi­otics sig­nif­i­cantly re­duced the risk of de­vel­op­ing sepsis. The pro­bi­otic used in the trial was Lac­to­bacil­lus plan­tarum. A very large meta-analy­sis in­ves­ti­gated the ef­fect of pro­bi­otics on pre­vent­ing late-on­set sep­sis (LOS) in neonates. Pro­bi­otics were found to re­duce the risk of LOS, but only in ba­bies who were fed human milk exclusively. It is dif­fi­cult to dis­tin­guish if the pre­ven­tion was a re­sult of the pro­bi­otic sup­ple­men­ta­tion or if it was a re­sult of the prop­er­ties of human milk. It is also still un­clear if pro­bi­otic ad­min­is­tra­tion re­duces LOS risk in ex­tremely low birth weight in­fants due to the lim­ited num­ber of stud­ies that in­ves­ti­gated it. Out of the 37 stud­ies in­...

  5. Sepsis - Wikipedia › wiki › Blood_poisoning

    Neonatal sepsis. In common clinical usage, neonatal sepsis refers to a bacterial blood stream infection in the first month of life, such as meningitis, pneumonia, pyelonephritis, or gastroenteritis, but neonatal sepsis also may be due to infection with fungi, viruses, or parasites.

    • Septicemia, blood poisoning
    • /ˈsɛpsɪs/
  6. Talk:Neonatal sepsis - Wikipedia › wiki › Talk:Neonatal_sepsis

    Talk:Neonatal sepsis. Ideal sources for Wikipedia's health content are defined in the guideline Wikipedia:Identifying reliable sources (medicine) and are typically review articles. Here are links to possibly useful sources of information about Neonatal sepsis. The TRIP database provides clinical publications about evidence-based medicine.

  7. Neonatal Sepsis - Lurie Children's Hospital of Chicago › neonatal-sepsis

    Neonatal Sepsis. Neonatal sepsis is a blood infection that occurs during the first 90 days of an infant’s life. It is especially common in preterm, low-birth-weight babies. It can be caused by bacteria or virus, most commonly Group B streptococcus but most dangerous when caused by E. coli. Symptoms are difficult to identify, but typically ...

  8. Neonatal intensive care unit - Wikipedia › wiki › Neonatal_intensive_care

    A neonatal intensive care unit (NICU), also known as an intensive care nursery (ICN), is an intensive care unit (ICU) specializing in the care of ill or premature newborn infants. Neonatal refers to the first 28 days of life. Neonatal care, as known as specialized nurseries or intensive care, has been around since the 1960s.

  9. Infection Probability Calculator - Neonatal Sepsis Calculator

    Probability of Neonatal Early-Onset Sepsis Based on Maternal Risk Factors and the Infant's Clinical Presentation. The tool below is intended for the use of clinicians trained and experienced in the care of newborn infants. Using this tool, the risk of early-onset sepsis can be calculated in an infant born > 34 weeks gestation. The interactive ...

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