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  1. www.ncbi.nlm.nih.gov › books › NBK219252The Anatomy and Physiology of Pain

    7. The Anatomy and Physiology of Pain. Pain is a subjective experience with two complementary aspects: one is a localized sensation in a particular body part; the other is an unpleasant quality of varying severity commonly associated with behaviors directed at relieving or terminating the experience. Pain has much in common with other sensory ...

  2. www.sciencedirect.com › neurophysiology-of-painNeurophysiology of Pain - an overview | ScienceDirect Topics

    Despite advances in understanding of the anatomy and neurophysiology of pain and the development of treatments based on sophisticated technology, chronic pain continues to be a prevalent and costly problem. Because chronic pain is a perceptual event, psychosocial and behavioral factors as well as physical ones contribute to the experience.

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  4. www.ncbi.nlm.nih.gov › pmc › articlesGeneral Pathways of Pain Sensation and the Major ...

    Jul 24, 2018 · The sensation of pain is associated with the activation of the receptors in the primary afferent fibers, which is inclusive of the unmyelinated C-fiber and myelinated Aσ-fiber. Both nociceptors remain silent during homeostasis in the absence of pain and are activated when there is a potential of noxious stimulus.

    • Mun Fei Yam, Yean Chun Loh, Chu Shan Tan, Siti Khadijah Adam, Nizar Abdul Manan, Rusliza Basir
    • 10.3390/ijms19082164
    • 2018
    • Int J Mol Sci. 2018 Aug; 19(8): 2164.

  5. link.springer.com › chapter › 10Chronic Pain: Pathophysiology and Mechanisms | SpringerLink

    Jan 5, 2018 · (a–c) Schematic drawing demonstrating the various mechanisms involved in neuropathic pain at different sites in the nociceptive pathway. Abbreviations: 5-HT 5-hydroxytryptamine, AMPA α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor, ASIC acid-sensing ion channel, ATP adenosine triphosphate, B bradykinin, CCL chemokine (C-C motif) ligand, CCR2 CC-chemokine receptor, Cl chloride ...

  6. www.msdmanuals.com › pain › overview-of-painOverview of Pain - Neurologic Disorders - MSD Manual ...

    Overview of Pain. By. , MD, Mayo Clinic College of Medicine and Science. Pain is the most common reason patients seek medical care. Pain has sensory and emotional components and is often classified as acute or chronic. Acute pain is frequently associated with anxiety and hyperactivity of the sympathetic nervous system (eg, tachycardia ...

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