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Mar 10, 2022 · Chagas disease can be treated with benznidazole (commercially available since May 14, 2018) or nifurtimox (2). Before January 25, 2021, nifurtimox (Lampit) had been exclusively available through CDC under an Institutional Review Board–approved Investigational New Drug (IND) treatment protocol, at which time it became reasonably accessible to ...
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Apr 6, 2021 · Only two drugs, nifurtimox and benznidazole, are currently known to be effective against Trypanosoma cruzi, the protozoan which causes Chagas disease.Both drugs were developed decades ago, involve long treatment durations of 60 days or more, and have frequent side effects, especially in adults.
- Faustino Torrico, Joaquim Gascón, Fabiana Barreira, Bethania Blum, Igor C Almeida, Cristina Alonso-V...
- 2021
Nov 12, 2020 · Treatment. Treatment for Chagas disease focuses on killing the parasite and managing signs and symptoms. During the acute phase of Chagas disease, the prescription medications benznidazole and nifurtimox (Lampit) may be of benefit. Both drugs are available in the regions most affected by Chagas disease. In the United States, however, the drugs ...
Nov 21, 2019 · Nifurtimox and benznidazole have been in use since the late 1960s, but their availability has repeatedly been compounded by shortages in production and distribution problems both in endemic and non-endemic regions, with a negative impact on patient access to therapy. 4, 5 To date, the FDA has only granted approval to benznidazole in the USA ...
- Yves-Laurent Julien Jackson, Baptiste Wyssa, François Chappuis
- 10.1093/jac/dkz473
- 2020
- 2020/03
Jan 10, 2024 · Treatment options are still limited to the nitroimidazole derivatives benznidazole and nifurtimox—benznidazole is the most used drug in most settings. On the basis of studies done in the late 1960s, the most frequently recommended benznidazole dosage and duration is 5–7mg/kg per day for 60 days.
Oct 1, 2015 · Coura, JR, de Abreu, LL, Willcox, HP, Petana, W. Comparative controlled study on the use of benznidazole, nifurtimox and placebo, in the chronic form of Chagas’ disease, in a field area with ...
