Search results
People also ask
How does nifurtimox work?
What are the side effects of nifurtimox?
Is nifurtimox an antiprotozoal drug?
Is Nifurtimox a plasma membrane transporter?
Oct 20, 2016 · Mechanism of action. The mechanism of action of nifurtimox has not been fully elucidated, however, is believed to occur by the activation of nitroreductase enzymes that produce reactive metabolites with a series of deleterious effects on Trypanosoma cruzi, the parasite causing Chagas disease. 6,10 The antiprotozoal actions of nifurtimox occur ...
Mechanism of action. Nifurtimox forms a nitro-anion radical metabolite that reacts with nucleic acids of the parasite causing significant breakdown of DNA. Its mechanism is similar to that proposed for the antibacterial action of metronidazole. Nifurtimox undergoes reduction and creates oxygen radicals such as superoxide.
- C₁₀H₁₃N₃O₅S
- By mouth
- Lampit
Jan 19, 2020 · With the trialling and implementation of NECT, the question of nifurtimox’ mode of action and potential resistance mechanism became one of acute importance. It had long been known that nitro-heterocyclic trypanocides can generate free radicals such as superoxide [ 168 ], although direct evidence of this being the principal mechanism of action ...
- Harry P. De Koning
- 10.3390/tropicalmed5010014
- 2020
- Trop Med Infect Dis. 2020 Mar; 5(1): 14.
The mechanism of action of nifurtimox appears to be related to its metabolism via partial reduction to chemically reactive radicals that cause production of toxic reduced products of oxygen. The metabolic products then can react with macromolecules such as DNA.
The mechanism of action of nifurtimox is not fully understood. Studies suggest that nifurtimox is metabolized/activated by type I (oxygen insensitive) and type II (oxygen sensitive) nitoreductases (NTR), leading to production of toxic intermediate metabolites and/or reactive oxygen species that induce DNA damage and cell death of both ...
Nifurtimox is a nitrofuran derivative which is readily reduced to a highly anion free radical that alkylates macromolecules such as nucleic acids and proteins resulting in the disruption of their structure and function.
In common with other nitrofurans, the mode of action of nifurtimox involves various reduction and oxidation reactions of its nitro constituent, leading to the production by parasite enzymes of a variety of reactive oxygen species that react with cellular macromolecules and are lethal to the parasite.
