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  1. Nifurtimox - Wikipedia

    Nifurtimox From Wikipedia, the free encyclopedia Nifurtimox, sold under the brand name Lampit, is a medication used to treat Chagas disease and sleeping sickness. For sleeping sickness it is used together with eflornithine in nifurtimox-eflornithine combination treatment.

    • C₁₀H₁₃N₃O₅S
    • Lampit
  2. Nifurtimox Drug Information, Professional

    Nifurtimox is better tolerated by younger patients. {20} {23} To minimize gastrointestinal irritation, nifurtimox should be taken after meals in 3 or 4 divided doses. {07} {10} {19} When treating infants, nifurtimox tablets should be crushed and mixed into some food at the beginning of a meal. {07}

  3. Nifurtimox - an overview | ScienceDirect Topics

    Nifurtimox is a nitrofuran derivative used to treat Chagas’ disease in humans. It has limited efficacy, with 70% parasitologic cure for acute disease and at best 20% for chronic disease.18 As with benznidazole, metabolic reduction of the nitro group by a trypanosome-specific nitroreductase leads to the formation of toxic metabolites.

  4. Nifurtimox Advanced Patient Information -
    • Description
    • Before Using This Medicine
    • Proper Use of This Medicine
    • Precautions While Using This Medicine
    • Side Effects of This Medicine

    Nifurtimox (nye-FER-tim-oks) belongs to a group of medicines called antiprotozoals. It is used to treat an infection called American trypanosomiasis (Chagas' disease). Nifurtimox works by killing the protozoa (tiny, one-celled animals) that cause the infection. Nifurtimox is available only with your doctor's prescription in the following dosage form: 1. Oral 2. Tablets (Argentina and Germany)

    In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For nifurtimox, the following should be considered: Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to nifurtimox. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes. Pregnancy—Studies have not been done in pregnant women. In animal studies, this medicine has not been shown to cause birth defects. However, when used in very large doses, nifurtimox caused a decrease in the weight of the offspring. Breast-feeding—It is not known whether nifurtimox passes into human breast milk. Although most medicines pass into breast milk in small amounts, many of them may be used safely while breast-feeding. Mothers who are taking this medicine and who wish to breast-feed should discuss this with their doctor. Children—Although there is no...

    Take this medicine with meals to decrease the chance of stomach upset. If you get an upset stomach and it does not go away after a short time, check with your doctor. To help clear up your infection, take this medicine exactly as directed by your doctor for the full time of treatment. When giving nifurtimox to infants, crush the tablets and mix them with some food at the beginning of a meal. Dosing—The dose of nifurtimox will be different for different patients. Follow your doctor's orders or the directions on the label . The following information includes only the average doses of nifurtimox. If your dose is different, do not change itunless your doctor tells you to do so. The number of tablets that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the severity of the medical problem for which you are taking nifurtimox. 1. For oral dosage form (tablets...

    It is important that your doctor check your progress at regular visits. This is to help make sure that the infection is cleared up completely. Also, your weight needs to be checked regularly by your doctor because nifurtimox can cause loss of appetite resulting in loss of weight. The dose of your medicine may have to be adjusted by your doctor based on your weight. If your symptoms become worse, check with your doctor. Drinking alcoholic beverages while taking this medicine may cause some unwanted effects. Other alcohol-containing preparations (for example, elixirs, cough syrups, tonics) may also cause problems. Therefore, do not drink alcoholic beverages or take other alcohol-containing preparations while you are taking nifurtimox.

    Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor as soon as possible if any of the following side effects occur: Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome: Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor. Revised: 04/25/1995

  5. Nifurtimox - Wikipedia

    Nifurtimox este un antibiotic și antiparazitar din clasa nitrofuranilor utilizat în tratamentul bolii Chagas (ca alternativă la benznidazol) și al bolii somnului. Calea de administrare disponibilă este cea orală. Nifurtimox a fost aprobat pentru uz medical în anul 1965.

    • 5.2M
    • 6.8M
    • 23256-30-6
    • M84I3K7C2O
  6. Study of Nifurtimox to Treat Refractory or Relapsed ...

    Jan 25, 2008 · Nifurtimox is a drug that has been used in South America for many years to treat a parasitic disease known as Chagas Disease.

  7. Nifurtimox - DrugFuture

    Literature References: Prepn from 5-nitrofurfural and 4-amino-3-methyltetrahydro-1,4-thiazine 1,1-dioxide: Herlinger et al., DE 1170957 corresp to US 3262930 (1964 and 1966 to Bayer).

  8. Nifurtimox | ≥99%(HPLC) | Selleck | Anti-infection chemical

    Nifurtimox (BAY-2502) is an antiprotozoal agent. Solubility (25°C) * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

  9. Nifurtimox | C10H13N3O5S | ChemSpider

    Predicted data is generated using the US Environmental Protection Agency’s EPISuite™. Log Octanol-Water Partition Coef (SRC): Log Kow (KOWWIN v1.67 estimate) = -0.34 Boiling Pt, Melting Pt, Vapor Pressure Estimations (MPBPWIN v1.42): Boiling Pt (deg C): 408.31 (Adapted Stein & Brown method) Melting Pt (deg C): 169.77 (Mean or Weighted MP) VP(mm Hg,25 deg C): 1.24E-007 (Modified Grain ...

  10. Nifurtimox | Parasite Inhibitor | MedChemExpress

    Nifurtimox, an antiprotozoal agent, which is generally used for the treatment of infections with Trypanosoma cruzi, has been used in the therapy of neuroblastoma. Nifurtimox affects enzyme activity of lactate dehydrogenase (LDH). For research use only. We do not sell to patients.

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