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The norepinephrine transporter (NET), also known as noradrenaline transporter (NAT), is a protein that in humans is encoded by the solute carrier family 6 member 2 (SLC6A2) gene. [5] NET is a monoamine transporter and is responsible for the sodium-chloride (Na + /Cl − )-dependent reuptake of extracellular norepinephrine (NE), which is also ...
- SLC6A2, NAT1, NET, NET1, SLC6A5, solute carrier family 6 member 2, Norepinephrine transporter, norepinephrine transporter gene
Inside the brain norepinephrine functions as a neurotransmitter and neuromodulator, and is controlled by a set of mechanisms common to all monoamine neurotransmitters. After synthesis, norepinephrine is transported from the cytosol into synaptic vesicles by the vesicular monoamine transporter (VMAT).
- C₈H₁₁NO₃
- dopamine
- 169.180 g·mol−1
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What is norepinephrine transporter?
Which neurotransmitter transports norepinephrine and dopamine?
Which ion-dependent transporter is responsible for norepinephrine transport in glial cells?
Where is the norepinephrine transporter gene located?
The norepinephrine transporter (NET) is a presynaptic transporter in sympathetic neurons that is important for the clearance of synaptic norepinephrine. A specific genetic abnormality has been identified in a kindred with hyperadrenergic POTS [4] .
Norepinephrine (NE) is the principle chemical messenger employed in central noradrenergic and peripheral sympathetic synapses. The norepinephrine transporter (NET), present on the plasma membrane of noradrenergic neurons, limits the action of NE through reuptake into the cytoplasm.
- Prashant Mandela, Gregory A. Ordway
- 2006
Jan 7, 2020 · The norepinephrine transporter (NET) is one of the monoamine transporters. Its X-ray crystal structure has not been obtained yet. Inhibitors of human NET (hNET) play a major role in the treatment of many central and peripheral nervous system diseases.
- Izabella Góral, Kamil Łątka, Marek Bajda
- 10.3390/biom10010102
- 2020
- Biomolecules. 2020 Jan; 10(1): 102.
Dopamine Norepinephrine TM6 Cl Norepinephrine C1 C2 Cβ Cα L-Norepinephrine Cα C1 Cβ C2 Dopamine Cl Na2 Na1 Norepinephrine F325 D121G F319 S426M S422 D46 A428 V120 Y124 F43 A117 3.5 3.8 3.8 2.5 ...
Jul 3, 2019 · MATs comprise three main members — the dopamine (DA) transporter (DAT) 1, 2, 3, serotonin transporter (SERT) 4, 5, 6 and norepinephrine transporter (NET) — which have critical roles in...
