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Why is dopamine a major neurotransmitter of the nucleus accumbens?
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Oct 30, 2023 · Dopamine has been shown to be the major neurotransmitter of the nucleus accumbens and plays an important role in the experience of reward and pleasure. The nucleus accumbens is thus associated with the mesolimbic dopamine pathway and is said to mediate the psychomotor effects of stimulant drugs and addiction.
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- Role of The Nucleus Accumbens in The ‘Reward Circuit ‘
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The nucleus accumbens (NAcc) is located in the basal forebrain and is a major structure of the ventral striatum, an area of the brain associated with the limbic system, and regulates limbic functionsof motivation, affect, and reward. There is a NAcc in each cerebral hemisphere, on the left and the right sides, and it is situated between the caudate...
The most widely recognized function of the NAcc is its role in the brain’s reward circuit.The NAcc is a component of a major dopamine pathway of the brain called the mesolimbic pathway. The mesolimbic dopamine pathway is stimulated during rewarding experiences. Essentially, when we do something which is rewarding, such as eating a favorite food or ...
The exact role of the NAcc in the processing of rewards is unclear and believed to be more complex than was originally thought. It is thought that the NAcc is likely involved in learning about rewards, as well as the stimuli that are associated with them. The NAcc also seems to be important in stimulating reward-seeking behaviors and the selection ...
Substance use disorders
Typically, with repeated exposure to a reward, the rewarding feeling will wane. However, with drugs of abuse, the functioning of the reward system can become overwhelming since the effects of these drugs do not wane after repeated exposure. This can be one of the reasons why people develop substance use disorders. Drugs of abuse tend to increase dopamine in the NAcc or change synaptic plasticity, whereas non-abused drugs generally do not affect dopamine in the NAcc or synaptic plasticity. The...
Mood disorders
As the NAcc is involved with cognitive and emotional functions, it may be involved in psychiatric conditions such as mood disorders. Patients with mood disorders have been found to have reduced NAcc activation (Heller et al., 2009). Patients with mood disorders were also found to have reduced NAcc volume in comparison to those without mood disorders (Baumann et al., 1999). A study used deep brain stimulation (a therapy for severe depression that proves resistant to other treatment methods) on...
Anxiety disorders
Due to connections to emotional regions of the brain, specifically the amygdala, the NAcc may be linked to anxiety conditions, which are also thought to be related to emotional regions. It was found that fear memories and anxiety induced by stress appear to be influenced by mechanisms in the NAcc (Du et al., 2019). Deep brain stimulation has been applied to the NAcc of patients with obsessive-compulsive disorder (OCD), an anxiety disorder, resulting in significant improvements of their sympto...
Berns, G. S., McClure, S. M., Pagnoni, G., & Montague, P. R. (2001). Predictability modulates human brain response to reward. Journal of neuroscience, 21(8), 2793-2798. Bewernick, B. H., Hurlemann, R., Matusch, A., Kayser, S., Grubert, C., Hadrysiewicz, B., Axmacher, N., Lemke, M., Cooper-Mahkorn, D., Cohen, M. X., Brockmann, H., Lenartz, D., Sturm...
Aug 23, 2022 · How dopamine (DA), a "reward" signal, releases during social behaviors has been a topic of interest for decades. Here, we use a genetically encoded DA sensor, GRAB DA2m, to record DA activity in the nucleus accumbens (NAc) core during various social behaviors in male and female mice.
Aug 8, 2022 · PMCID: PMC9511885. NIHMSID: NIHMS1832194. PMID: 36001967. Responses and functions of dopamine in nucleus accumbens core during social behaviors. Bing Dai, 1,* Fangmiao Sun, 2,3,4 Xiaoyu Tong, 1 Yizhuo Ding, 1 Amy Kuang, 1 Takuya Osakada, 1 Yulong Li, 2,3,4 and Dayu Lin 1,5,6,7,* Author information Copyright and License information PMC Disclaimer.
- 10.1016/j.celrep.2022.111246
- 2022/08/08
Jul 28, 2022 · Nature Neuroscience - Kutlu, Zachry, Melugin et al. show that dopamine in the nucleus accumbens core is evoked by novel, neutral stimuli and tracks stimulus familiarity in the absence of...
The Nucleus Accumbens: An Interface Between Cognition, Emotion, and Action. Stan B. Floresco 1. View Affiliations. Vol. 66:25-52 (Volume publication date January 2015) https://doi.org/10.1146/annurev-psych-010213-115159. First published as a Review in Advance on September 17, 2014. © Annual Reviews. info Info. list Sections. PDF. build Tools.
Sep 15, 2021 · Dopamine release in the nucleus accumbens core signals perceived saliency. Highlights. •. NAc core dopamine only mimics reward prediction error in select reward contexts. •. RPE does not model dopamine release during negative reinforcement. •. Dopamine signaling in the NAc core does not support valence-free prediction error. •.
