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- He dissected out of frogs two beating hearts: one with the vagus nerve which controls heart rate attached, the other heart on its own. Both hearts were bathed in a saline solution (i.e. Ringer's solution). By electrically stimulating the vagus nerve, Loewi made the first heart beat slower.
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In that famous experiment, Loewi placed two beating frog hearts, each in its own perfusion chamber – one preparation had the vagus nerve intact, while the other was denervated. Next, he stimulated the vagus nerve supplying the first heart, causing it to beat more slowly – a phenomenon that was already well known at the time.
- Alli N McCoy, Siang Yong Tan
- 10.11622/smedj.2014002
- 2014
- Singapore Med J. 2014 Jan; 55(1): 3-4.
In his most famous experiment, Loewi took fluid from one frog heart and applied it to another, slowing the second heart and showing that synaptic signaling used chemical messengers. The Nobel Prize diploma of Otto Loewi, housed at the University of Graz
May 27, 2021 · The paper reported an ingenious, yet straightforward experiment made by Professor Otto Loewi in 1920 and published in 1921, which constitutes the first clear-cut proof for the chemical nature of transmission of the nerve impulse from nerve to muscle.
- Ricardo Borges, Antonio G. García
- 2021
Back in 1921, an Austrian scientist named Otto Loewi discovered the first neurotransmitter. In his experiment (which came to him in a dream), he used two frog hearts. One heart (heart #1) was still connected to the vagus nerve. Heart #1 was placed in a chamber that was filled with saline.
Oct 1, 2018 · Otto Loewi (1873-1961) was a German pharmacologist. He is best known for his characterization of acetylcholine as the chemical substance that influences the rate of a heart beating in frogs, an experiment that was first published in 1921.
Loewi performed a very simple yet elegant experiment. Using an isolated frog heart he had previously found that stimulation of the vagus nerve resulted in a slowing of the heart rate, while stimulation of the sympathetic nerve caused the heart rate to speed up (Figure 1).
Mar 22, 2024 · His neurological researches (1921–26) provided the first proof that chemicals were involved in the transmission of impulses from one nerve cell to another and from neuron to the responsive organ. He and his colleagues, by stimulating the nerves in the heart of a frog, slowed the heart’s rate of contraction.
