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We review many of the recent findings concerning mechanisms and pathways for pain and its modulation, emphasizing sensitization and the modulation of nociceptors and of dorsal horn nociceptive neurons.
The pain pathway, as classically understood, consists of a three-neuron chain that transmits pain signals from the periphery to the cerebral cortex.
Introduction . Pain is a vital function of the nervous system in providing the body with a warning of potential or actual injury. It is both a sensory and emotional experience, affected by psychological factors such as past experiences, beliefs about pain, fear or anxiety.
