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Jul 24, 2018 · There are multiple levels of CNS involved in the transmission of pain. These include the spinal cord (supraspinal), the brainstem (midbrain, medulla oblongata and the pons), and the cortical regions (cerebral cortex), as shown in Figure 1.
- Mun Fei Yam, Yean Chun Loh, Chu Shan Tan, Siti Khadijah Adam, Nizar Abdul Manan, Rusliza Basir
- 10.3390/ijms19082164
- 2018
- Int J Mol Sci. 2018 Aug; 19(8): 2164.
We describe the organization of several ascending nociceptive pathways, including the spinothalamic, spinomesencephalic, spinoreticular, spinolimbic, spinocervical, and postsynaptic dorsal column pathways in some detail and discuss nociceptive processing in the thalamus and cerebral cortex.
- W D Willis, K N Westlund
- 10.1097/00004691-199701000-00002
- 1997
- 1997/01
Nov 10, 2021 · Given the known differential expression of δ and μ receptors in the brain’s pain pathways ( 35, 36 ), these results suggested that distinct circuits (and molecules in these circuits) control different nocifensive behaviors during the hotplate pain experience.
- Nicole Mercer Lindsay, Nicole Mercer Lindsay, Chong Chen, Gadi Gilam, Sean Mackey, Grégory Scherrer
- 2021
Jun 26, 2019 · Ascending pathway (red line): A nerve pathway that projects upwards from the spinal cord to the brain carrying sensory information from the body to the brain. Pain signals ascend from the spinal dorsal horn to the rostral ventral medulla (RVM) and periaqueductal grey matter (PAG).
- Seoyon Yang, Min Cheol Chang
- 10.3390/ijms20133130
- 2019
- Int J Mol Sci. 2019 Jul; 20(13): 3130.
Mar 13, 2019 · Results Pain pathways represent a complex sensory system with cognitive, emotional, and behavioral influences. Anatomically, the hippocampus, amygdala, and anterior cortex—central to the encoding and consolidation of memory—are also implicated in experiential aspects of pain.
- Bill McCarberg, John Peppin
- 2019
Objective. To review the pain pathways in the central and peripheral nervous system and the actions of drugs used to treat pain. Design. An overview of pain pathways is presented, beginning in the periphery and progressing centrally, and the ascending and descending pathways are described in detail. Results.
A sensory neuron—or nociceptor—transmits an electrical impulse to the spinal cord and then to the brain, where it is experienced as pain. Inflammatory pain results from infection or tissue injury, leading to activation of the immune system.