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Feb 5, 2016 · Paul Ehrlich's contributions to science undoubtedly paved the way to a new era of medicine, where cellular features and functions were linked to specific molecules, and translational concepts were established based on mechanistic and molecular insights into the pathophysiology of the disease and specific molecular interactions, including drug ...
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PMC full text: J Innate Immun. 2016 Mar; 8(2): 111–120....
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Leading scientists working at the time of Paul Ehrlich...
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Paul Ehrlich's theories and concepts and their impact on the...
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Historical overview of Paul Ehrlich's life and achievements....
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- Early Work with Dyes
- Antitoxins from Blood Sera
- A Nobel Prize and Magic Bullets
- Chemotherapy
- Salvarsan
Ehrlich was born near Breslau—then in Germany, but now known as Wrocław, Poland. He studied to become a medical doctor at the university there and in Strasbourg, Freiburg im Breisgau, and Leipzig. In Breslau he worked in the laboratory of his cousin Carl Weigert, a pathologist who pioneered the use of aniline dyes as biological stains. Ehrlich beca...
After a bout with tuberculosis and his subsequent cure with tuberculin therapy, developed by fellow German Robert Koch, Ehrlich focused his attention on bacterial toxins and antitoxins. At first he worked in a small private laboratory, but then he was invited to work at Koch’s Institute for Infectious Diseases in Berlin. The post-Pasteurera was an ...
In 1908 Ehrlich shared the Nobel Prize in Physiology or Medicinewith Élie Metchnikoff for their separate paths to an understanding of the immune response: Ehrlich presented a chemical theory to explain the formation of antitoxins, or antibodies, to fight the toxins released by the bacteria, while Metchnikoff studied the role of white blood corpuscl...
Serum therapy was for Ehrlich the ideal method of contending with infectious diseases. In those cases, however, in which effective sera could not be discovered, Ehrlich would turn to synthesizing new chemicals, informed by his theory that the effectiveness of a therapeutic agent depended on its side chains. These “chemotherapies” were to be the new...
The researchers, now including an organic chemist, Alfred Bertheim, and a bacteriologist, Sahashiro Hata, broadened the targeted microorganisms to include spirochetes, which had recently been identified as the cause of syphilis. Beginning with an arsenic compound, atoxyl, in three years’ time and three hundred syntheses later—for that day an amazin...
He also made a decisive contribution to the development of an antiserum to combat diphtheria and conceived a method for standardizing therapeutic serums. [1] In 1908, he received the Nobel Prize in Physiology or Medicine for his contributions to immunology. [2] .
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Mar 10, 2024 · Paul Ehrlich was a German medical scientist known for his pioneering work in hematology, immunology, and chemotherapy and for his discovery of the first effective treatment for syphilis. He received the Nobel Prize for Physiology or Medicine in 1908 jointly with Élie Metchnikoff.
Feb 29, 2024 · Paul R. Ehrlich, American biologist and educator who in 1990 shared Sweden’s Crafoord Prize with biologist E.O. Wilson. Though much of his research was done in the field of entomology, Ehrlich’s overriding concern became unchecked population growth. Learn more about his life and career.
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Oct 1, 2022 · Nobel Prize. Innate Immunity. Hemolysis. Bacteriolysis. Microbial Lysis. 1. Paul Ehrlich’s Life. Paul Ehrlich was born on March 14, 1854, in Strehlen, near Breslau (at that time part of Germany, but now part of Poland), and was the son of a Jewish liqueur manufacturer and royal lottery taker.
Jul 1, 2008 · Abstract. One hundred years ago the birth of immunology was made official by the Nobel Prize award to Elie Metchnikoff and Paul Ehrlich. Metchnikoff discovered phagocytosis by macrophages and...
