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Feb 13, 2024 · Learn about the possible side effects of Paxlovid, a COVID-19 treatment that includes nirmatrelvir and ritonavir. Find out how to manage them, what to report to your doctor, and how Paxlovid may interact with other medications.
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- kathy.katella-cofrancesco@yale.edu
- How does Paxlovid work? Paxlovid is an antiviral therapy that consists of two separate medications packaged together. When you take your three-pill dose, two of those pills will be nirmatrelvir, which inhibits a key enzyme that the COVID virus requires in order to make functional virus particles.
- When should I take Paxlovid? You have to take Paxlovid within five days of developing symptoms. Like all antivirals, Paxlovid works best early in the course of an illness—in this case, within the first five days of symptom onset, says Jeffrey Topal, MD, a Yale Medicine infectious diseases specialist who is involved in determining COVID-19 treatment protocols for Yale New Haven Hospital patients.
- How often do I take Paxlovid? The standard dose is three Paxlovid pills twice daily for five days for a full course that adds up to 30 pills. It helps that the pills are packaged in a “dose card,” basically a medication blister pack that allows you to punch out the pills as needed.
- Is Paxlovid similar to Tamiflu? “I think it's a good comparison,” says Dr. Roberts. Tamiflu is an antiviral drug that reduces flu symptoms. Both are prescription-only oral antiviral pills given early in illness.
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Paxlovid (EUA) is a combination of nirmatrelvir and ritonavir used to treat mild to moderate COVID-19 in high-risk patients. It may cause changes in taste, diarrhea, or liver problems. It can interact with many other drugs and should be used with caution.
PAXLOVID is a medicine for mild-to-moderate COVID-19 in adults and children who are at high risk for severe disease. Learn about the risks and benefits of taking PAXLOVID, the interactions with other medicines, and how to report side effects or problems with the appearance or packaging of PAXLOVID.
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