1-Phenylcyclohexylamine | C12H17N | CID 31862 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
May 1, 2002 · Synthesis and anticonvulsant activity of 1-phenylcyclohexylamine analogs Andrew Thurkauf , Brian De Costa , Shunichi Yamaguchi , Mariena V. Mattson , Arthur E. Jacobson , Kenner C. Rice , and Michael A. Rogawski
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- Introduction
- Results and Discussion
- Conclusions
- Experimental
- Acknowledgements
Chiral amines are a privileged functional group, ubiquitous in natural products, pharmaceuticals, agrochemicals and fine chemicals.1 Consequently, the discovery and development of more efficient ways to synthesise chiral amines continues to be a major research topic in synthetic chemistry. In this context, biocatalysis offers an alternative to conv...
The two target enzymes in this study, NfRedAm from Neosartorya fumigatus and NfisRedAm from Neosartorya fischeri, each displayed excellent levels of expression in E. coli BL21(DE3). The initial report, suggesting that these enzymes may display some activity for the reduction of the imine resulting from the ambient reaction of acetophenone and ammon...
The activity of two enzymes from the fungal reductive aminase (RedAm) clade, NfRedAm and NfisRedAm, has been characterised. While they possess a similar substrate scope to previously described RedAms in the reductive amination with primary amines, their ability to enable the reductive amination of ketones using ammonia was found to be much higher. ...
Gene expression and protein purification
The plasmids containing the genes for target enzymes were used to transform E. coli BL21(DE3) competent cells for gene expression. Pre-cultures were grown in LB-medium (5 mL) containing 30 μg mL−1 kanamycin for 18 h at 37 °C with shaking at 180 rpm. 0.6 L volume cultures were inoculated with the pre-culture (6 mL) and incubated at 37 °C, with shaking at 180 rpm until an OD600 of 0.6–0.8 was reached. Gene expression was induced by addition of IPTG (1 mM) and shaking was continued overnight at...
RedAm-catalysed bio-reductive amination
A 500 μL reaction mixture contained 20 mM d-glucose, 0.5 mg mL−1 GDH (Codexis, CDX-901), 0.5 mM NADP+, 1 mg mL−1 purified RedAm, 10 mM ketone, in 1 M NH4Cl pH 9 NaPi buffer adjusted and 2% v/v DMSO. Reactions were incubated at 30 °C with 250 rpm shaking for 24 h, after which they were quenched by the addition of 30 μL of 10 M NaOH and extracted twice with 500 μL tert-butyl methyl ether. The organic fractions were combined and dried over anhydrous MgSO4and analysed by HPLC or GC-FID on a chira...
J. M.-S. and M. S. were funded by grant BB/M006832/1 from the UK Biotechnology and Biological Sciences Research Council. N. J. T. is grateful to the ERC for the award of an Advanced Grant (Grant number 742987). S. C. C. would like to acknowledge the EPSRC UK Catalysis Hub for funding. We also thank Dr James Galman from the Manchester Institute of B...
- Juan Mangas-Sanchez, Mahima Sharma, Sebastian C. Cosgrove, Jeremy I. Ramsden, James R. Marshall, Tho...
- 2020
Mar 14, 2022 · Get free biology notes, worksheets, quizzes, and slides that you can download and print. This is a collection of free biology worksheets, notes, handouts, slides, study guides and quizzes. Most content targets high school, AP biology, genetics, anatomy/physiology, immunology, and biology 101 and 102 in college.
An arylcyclohexylamine is composed of a cyclohexylamine unit with an aryl moiety attachment. The aryl group is positioned geminal to the amine. In the simplest cases, the aryl moiety is typically a phenyl ring, sometimes with additional substitution. The amine is usually not primary; secondary amines such as methylamine or ethylamine, or ...
Synthesis of PCP from PCA via 1-phenylcyclohexanol (PCOH) The PCOH starting material can be purchased or prepared by reaction of phenyllithium or phenyl grignard with cyclohexanone. This alcohol is then be transformed into the amine by reaction with sodium azide (~90% yield) followed by reduction.
Abstract. Various 1-arylcyclohexylamines were synthesized for evaluation as central nervous system depressants. The compounds were prepared by several procedures. 1- (1-Phenylcyclohexyl)piperidine, the first compound of this type synthesized, was prepared from 1-piperidinocyclohexanecarbonitrile by replacement of the cyano group by phenyl using ...
May 1, 1990 · Synthesis, radiosynthesis, and biological evaluation of fluorinated thienylcyclohexyl piperidine derivatives as potential radiotracers for the NMDA receptor-linked calcium ionophore. Nuclear Medicine and Biology 1996, 23 (3) , 315-324.
RNA is a small molecule that can squeeze through pores in the nuclear membrane. It carries the information from DNA in the nucleus to a ribosome in the cytoplasm and then helps assemble the protein. In short: DNA → RNA → Protein Discovering this sequence of events was a major milestone in molecular biology.
Journal Published Online: 01 September 1989 Volume 34, Issue 5 Characterization of -Ethyl-1-Phenylcyclohexylamine Reaction Components CODEN: JFSCAS Abstract Impurities found in the two principal methods of the manufacture of N -ethyl-1-phenylcyclohexylamine (cyclohexamine, PCE) are identified.
Different types of reaction coupling in the cell. The example above shows how ATP hydrolysis can be coupled to a biosynthetic reaction. However, ATP hydrolysis can also be coupled to other classes of cellular reactions, such as the shape changes of proteins that transport other molecules into or out of the cell.
Jun 23, 2019 · Transduction: When the signaling molecule binds the receptor it changes the receptor protein in some way. This change initiates the process of transduction. Signal transduction is usually a pathway of several steps. Each relay molecule in the signal transduction pathway changes the next molecule in the pathway. 3.
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