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  1. 1-Phenylcyclohexylamine | C12H17N - PubChem Apologies, we are having some trouble retrieving data from our servers... PUGVIEW FETCH ERROR: 403 Forbidden National Center for Biotechnology Information 8600 Rockville Pike, Bethesda, MD, 20894 USA Contact Policies FOIA HHS Vulnerability Disclosure National Library of Medicine

  2. 1-Phenylcyclohexylamine hydrochloride | C12H18ClN | CID 200391 - structure, chemical names, physical and chemical properties, classification, patents, literature ...

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  4. › 40632_CH08_rev151_188Jones & Bartlett Learning

    Jones & Bartlett Learning

    • 9MB
    • 38
    • Introduction
    • Results and Discussion
    • Conclusions
    • Experimental
    • Acknowledgements

    Chiral amines are a privileged functional group, ubiquitous in natural products, pharmaceuticals, agrochemicals and fine chemicals.1 Consequently, the discovery and development of more efficient ways to synthesise chiral amines continues to be a major research topic in synthetic chemistry. In this context, biocatalysis offers an alternative to conv...

    The two target enzymes in this study, NfRedAm from Neosartorya fumigatus and NfisRedAm from Neosartorya fischeri, each displayed excellent levels of expression in E. coli BL21(DE3). The initial report, suggesting that these enzymes may display some activity for the reduction of the imine resulting from the ambient reaction of acetophenone and ammon...

    The activity of two enzymes from the fungal reductive aminase (RedAm) clade, NfRedAm and NfisRedAm, has been characterised. While they possess a similar substrate scope to previously described RedAms in the reductive amination with primary amines, their ability to enable the reductive amination of ketones using ammonia was found to be much higher. ...

    Gene expression and protein purification

    The plasmids containing the genes for target enzymes were used to transform E. coli BL21(DE3) competent cells for gene expression. Pre-cultures were grown in LB-medium (5 mL) containing 30 μg mL−1 kanamycin for 18 h at 37 °C with shaking at 180 rpm. 0.6 L volume cultures were inoculated with the pre-culture (6 mL) and incubated at 37 °C, with shaking at 180 rpm until an OD600 of 0.6–0.8 was reached. Gene expression was induced by addition of IPTG (1 mM) and shaking was continued overnight at...

    RedAm-catalysed bio-reductive amination

    A 500 μL reaction mixture contained 20 mM d-glucose, 0.5 mg mL−1 GDH (Codexis, CDX-901), 0.5 mM NADP+, 1 mg mL−1 purified RedAm, 10 mM ketone, in 1 M NH4Cl pH 9 NaPi buffer adjusted and 2% v/v DMSO. Reactions were incubated at 30 °C with 250 rpm shaking for 24 h, after which they were quenched by the addition of 30 μL of 10 M NaOH and extracted twice with 500 μL tert-butyl methyl ether. The organic fractions were combined and dried over anhydrous MgSO4and analysed by HPLC or GC-FID on a chira...

    J. M.-S. and M. S. were funded by grant BB/M006832/1 from the UK Biotechnology and Biological Sciences Research Council. N. J. T. is grateful to the ERC for the award of an Advanced Grant (Grant number 742987). S. C. C. would like to acknowledge the EPSRC UK Catalysis Hub for funding. We also thank Dr James Galman from the Manchester Institute of B...

    • Juan Mangas-Sanchez, Mahima Sharma, Sebastian C. Cosgrove, Jeremy I. Ramsden, James R. Marshall, Tho...
    • 2020
  5. Several analogues of 1-phenylcyclohexylamine (PCA), a phencyclidine (PCP) derivative, exhibited a greater separation of potencies in the motor toxicity and MES seizure tests than did the parent compound PCA. Thirty-eight analogues of 1-phenylcyclohexylamine (PCA), a phencyclidine (PCP) derivative, were examined for their activities in the mouse maximal electroshock (MES) seizure test and in a ...

  6. thesis of 1-phenylcyclohexylamine. The compound prepared by the alternate route (method F) was identi- cal in all respects with the one obtained prepared from Method F aC6"I NCO - CxCeH5 "2 VI phenylcyclohexene. Recently, Cristol, et ul., re- ported the isolation of the amine as its benzoyl deriva- tive via a modified Ritter reaction.

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