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Apr 2, 2013 · Classic examples of psychoactive arylcycloalkylamines include ketamine and 1-(1-phenylcyclohexyl)piperidine (PCP) and many others serve as important structural templates for neuropharmacological research.
- Jason Wallach, Giorgia De Paoli, Adeboye Adejare, Simon D. Brandt
- 2014
Example: Synthesis of PCE (N-ethyl-1-phenylcyclohexylamine): A mixture of 100 g of anhydrous ethylamine and 220 g of cyclohexanone was kept 16 hours, then shaken with solid KOH. The lower oil layer, which comprises the imine ( N-cyclohexylidenethylamine), was then removed by decantation.
Example. Planning a Synthesis using a Hoffman or Curtius Rearrangement. Because the amide and the acyl azide required for these rearrangements both are best made from an acid chloride, synthesis of amines using these reaction are best started from the corresponding carboxylic acid.
As examples, BTCP is a selective dopamine reuptake inhibitor, PCP is primarily an NMDA antagonist, and BDPC is a potent μ-opioid agonist, while PRE-084 is a selective sigma receptor agonist. Thus, radically different pharmacology is possible through different structural combinations.
CompoundAryl SubstituentN GroupCyclohexyl Ring2-HO-PCPPhenylPiperidine2-Hydroxy2-Me-PCPPhenylPiperidine2-Methyl2-MeO-PCPPhenylPiperidine2-Methoxy2-Keto-PCPPhenylPiperidine2-KetoPeople also ask
Which arylcyclohexylamine was first synthesised?
When was phenyl cyclohexylamine used?
What are some examples of psychoactive arylcycloalkylamines?
What is arylcyclohexylamine?
An attractive procedure from the standpoint of clandestine synthesis would be the reductive alkylation of PCA with acetone and aluminum amalgam to give the potent analog N-isopropyl phenylcyclohexylamine. The first method using PCA as an intermediate is Scheme IV.
Jan 1, 2016 · The most well-characterized arylcyclohexamines are phencyclidine ( (1- (1-phencyclohexyl) piperidine; PCP )), ketamine, and, of the novel analogues, methoxetamine. Chemical structures of the primary arylcyclohexamines: phencyclidine , ketamine , and methoxetamine.
May 1, 1990 · Thirty-eight analogues of 1-phenylcyclohexylamine (PCA), a phencyclidine (PCP) derivative, were examined for their activities in the mouse maximal electroshock (MES) seizure test and in a motor-toxicity assay.
