1-Phenylcyclohexylamine | C12H17N | CID 31862 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological ...
Phenylcyclohexylamine produced a long-lasting dose-dependent biphasic effect on the efflux of DA in the rat. This response, to one of the major metabolites of phencyclidine, was similar in duration to but less potent than that seen with phencyclidine. Publication types Research Support, U.S. Gov't, P.H.S. MeSH terms Animals
Laboratory Chemical Safety Summary (LCSS) Datasheet. Molecular Formula. C12H18ClN. Synonyms. 1-Phenylcyclohexylamine hydrochloride. 1934-71-0. 1-phenylcyclohexanamine hydrochloride. CI 401. 1-phenylcyclohexan-1-amine hydrochloride.
1-phenylcyclohexylamine (pca), an analog of phenyclidine (pcp) in which the piperidine ring is replaced by a primary amino group, and its conformationally restricted analog 1,1-pentamethylenetetrahydroisoquinoline (pm-thiq) were potent anticonvulsants in the mouse maximal electroshock (mes) seizure test (ed50 values, 7.0 and 14.3 mg/kg, …
- Michael A Rogawski, A. Thurkauf, S. I. Yamaguchi, K. C. Rice, A. E. Jacobson, M. V. Mattson
Synthesis of PCP from PCA via 1-phenylcyclohexanol (PCOH) The PCOH starting material can be purchased or prepared by reaction of phenyllithium or phenyl grignard with cyclohexanone. This alcohol is then be transformed into the amine by reaction with sodium azide (~90% yield) followed by reduction.
Mar 23, 2022 · Thyroid Hormone Synthesis Pathway: Step 2 - The thyrotropes of the anterior pituitary gland release thyroid-stimulating hormone (TSH) into the bloodstream, which will stimulate the thyroid gland. Step 3 - Thyroid Hormone Synthesis (Thyroid Gland)
Phencyclidine (PCP) is believed to be the first arylcyclohexylamine with recognized anesthetic properties, but several arylcyclohexylamines were described before PCP in the scientific literature, beginning with PCA (1-phenylcyclohexan-1-amine) the synthesis of which was first published in 1907.