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thesis of 1-phenylcyclohexylamine. The compound prepared by the alternate route (method F) was identi- cal in all respects with the one obtained prepared from Method F aC6"I NCO - CxCeH5 "2 VI phenylcyclohexene. Recently, Cristol, et ul., re- ported the isolation of the amine as its benzoyl deriva- tive via a modified Ritter reaction.
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Alkylation is an efficient method for the synthesis of 3 o and 4 o amines. However, when 1 o and 2 o amines are alkylated a mixture of products is typically produced. When ammonia is reacted with an alkylhalide an monoalkylammonium salt is formed. RX + NH 3 → RNH 3+ + X -.
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Jan 1, 2016 · The first arylcyclohexamine to be described was 1-(1-phenylcyclohexyl) amine, in 1907, almost 50 years before the synthesis of PCP . Other analogues reported in the early 1950s included N-ethyl-1-phenylcyclohexylamine (PCE) and 1-(1-phenylcyclohexyl)morpholine (PCMo). While many were not explored further by their initial investigators, chemists ...
Various 1-arylcyclohexylamines were synthesized for evaluation as central nervous system depressants and tested for cataleptoid activity and antitonic extensor properties. Various 1-arylcyclohexylamines were synthesized for evaluation as central nervous system depressants. The compounds were prepared by several procedures. 1-(1-Phenylcyclohexyl)piperidine, the first compound of this type ...
Reaction schemes with PCA intermediate. The next three routes use PCA (1-phenyl cyclohexylamine) as a precursor for either PCP or other analogs. PCA itself is an active compound, and has been under clinical study as a potential anesthetic agent. It is approximately one half as potent than PCP and appears to have similar actions.
Apr 2, 2013 · Drug Testing and Analysis is a specialist journal covering sports doping, recreational drugs, pharmaceuticals, toxico-pathology, forensics, and the environment.
May 1, 1990 · Several analogues of 1-phenylcyclohexylamine (PCA), a phencyclidine (PCP) derivative, exhibited a greater separation of potencies in the motor toxicity and MES seizure tests than did the parent compound PCA. Thirty-eight analogues of 1-phenylcyclohexylamine (PCA), a phencyclidine (PCP) derivative, were examined for their activities in the mouse maximal electroshock (MES) seizure test and in a ...
