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Apr 2, 2013 · The present study describes the synthesis of three substituted 1-(1-phenylcyclohexyl)piperidines, (3-MeO-, 4-MeO- and 3-Me-PCP) and three substituted 1-(1-phenylcyclohexyl)pyrrolidine analogues (3-MeO-, 4-MeO- and 3-Me-PCPy).
- Jason Wallach, Giorgia De Paoli, Adeboye Adejare, Simon D. Brandt
- 19
- 2014
- 02 April 2013
An attractive procedure from the standpoint of clandestine synthesis would be the reductive alkylation of PCA with acetone and aluminum amalgam to give the potent analog N-isopropyl phenylcyclohexylamine. The first method using PCA as an intermediate is Scheme IV.
Mar 3, 2018 · In this review, we present mechanistic studies, chemical methodologies and reagents for the synthesis of isocyanates from carboxylic acids, conversion of isocyanates to amines and amine derivatives, and their applications in the synthesis of bioactive natural products and their congeners.
- Arun K. Ghosh, Anindya Sarkar, Margherita Brindisi
- 10.1039/c8ob00138c
- 2018
- 2018/03/03
This is the best route for synthesis of compounds with mono N-alkyl substituents, such as PCE (ref. 10). An intermediate imine is formed by the reaction of cyclohexanone and the appropriate primary amine. The phenyl group can then be introduced with phenyllithium (ref 15, 16).
Jan 1, 2016 · Arylcyclohexamines (also known as arylcyclohexylamines) are a group of compounds that contain a cyclohexamine unit with an aryl moiety, typically a phenyl ring, attached to the same atom to which the amine group is linked (see Fig. 1).
Here, a powerful one‐pot Raney Ni‐based catalytic strategy was developed to transform guaiacol into cyclohexylamine using NH3 (7 bar) and H2 (10 bar) in up to 94 % yield. The methodology was ...
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Thirty-eight analogues of 1-phenylcyclohexylamine (PCA), a phencyclidine (PCP) derivative, were examined for their activities in the mouse maximal electroshock (MES) seizure test and in a motor-toxicity assay. In addition, we determined the binding affinities of the compounds for PCP acceptor sites in rat brain membranes labeled with [3H]-1- [1 ...
