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May 15, 2024 · 1,4-cis-Disubstituted cyclic compounds play a pivotal role in pharmaceutical development, offering enhanced potency and bioavailability. However, their stereoselective and modular synthesis remains a long-standing challenge. Here, we report an innovative strategy for accessing these structures via mild conditions employing cyclic 1,3-dienes/alkyl(aryl)halides and amines. This procedure ...
6 days ago · In photosynthetic organisms, L-ascorbic acid is produced in the Smirnoff-Wheeler pathway by the multi-step conversion of D-mannose-6-phosphate to L-galactono-1,4-lactone, the substrate for the ...
Apr 27, 2024 · The REG system, played a crucial role in facilitating this green synthesis process. By providing a suitable reaction environment, the REG system allowed for the efficient and rapid formation of ...
May 15, 2024 · Electrophilic aromatic substitution (SEAr) and nucleophilic aromatic substitution (SNAr) reactions are among the most valuable reactions in the conversion of aromatic rings. While these reactions are typically covered in separate experiments in undergraduate organic courses, a continuous experimental setup elucidating both SEAr and SNAr processes remains unexplored in the literature for ...
Apr 25, 2024 · Abstract. The aberrant activation of the PI3K/mTOR signaling pathway is implicated in various human cancers. Thus, the development of inhibitors targeting mTOR has attracted considerable attention. In this study, we used a structure-based drug design strategy to discover a highly potent and kinase-selective mTOR inhibitor 24 ( PT-88 ), which ...
4 days ago · The low yield in the synthesis represents a higher cost in obtaining the material and a more elaborate process to get significant amounts of the biosorbent. The low yield is a consequence of the catalytic capacity of HNO 3 in the reduction of lignocellulosic material [ 64 ], causing the reduction of helpful surface area [ 65 ].
May 8, 2024 · The spinel structure of LiMe 3+ O 2 differs from Li 0.5 Me 3.5+ O 2, in which Li is stabilized in tetrahedral sites because of the stronger electrostatic repulsion from Me ions in a higher average ...
